GLG News by ONC-Avastin Prescribers for Colorectal Cancer (US)

Brain metastases occur commonly in patients with NSCLC.  Current therapy is limited to the use of whole brain radiation therapy for patients with multiple brain metastases.  Standard chemotherapy agents work poorly in brain metastases from NSCLC.   Azixa acts as a vascular disrupting...

"The FDA announced that studies of two prescription proton-pump inhibitors, omeprazole (Prilosec) and esomeprazole (Nexium), had raised concerns about their cardiovascular safety. In the same announcement, the agency said its preliminary assessment was that the problems seen in those studies were "not...

Because of the high cost of medical care in the United States, some individuals have sought care in other countries where out of pocket costs for the treatment can be markedly lower.  However, outcomes results with this apprach are largely anecdotal and the few studies that examine this approach...

Velcade is an effective and tolerable agent with excellent clinical activity in relasped or previously untreated multiple myeloma.  The current phase III EVOLVE trial will randomize patients with previously untreated myeloma to receive either velcade, lenalidomide / dexamethasone or velcade, lenalidomide...

In 2008, Medicare will no longer pay the cost for hospital care related to certain types of errors including some hospital acquired infections.  This continued decrease in reimbursement will hurt those hospitals most in need of new information systems and increased staffing.

Coumadin is a frequently used and efficacious anticoagulant but patients must be monitored closely in order to avoid bleeding complications.  Genetic variations in coumadin metabolism contribute significantly to variations in bleeding risk and sensitivity to the anticoagulant effects of the drug. ...

1.  Nimotuzumab is a humanized monoclonal antibody targeting the EGFR receptor.  This receptor is over-expressed in more than 50% of gliomas or high grade brain tumors 2.  A phase II clinical trial has demonstrated partial responses and clinical benefit in pediatric patients with recurrent...

Carfilzomib is a proteosome inhibitor like Velcade.  Unlike Velcade, Carfilzomib has shown minimal cross-reactivity with the other catalytic sites within the proteasome or across other protease classes.  Phase I trials have shown that carfilzomib has activity in previously treated myeloma...

TASQ is an oral agent for the treatment of metastatic prostate cancer.  Oral agents against this disease could capture a sizable market if safe and effective.

The comprehensive clinical program will supplement the significant body of clinical data existing for ERBITUX in colorectal and head and neck cancers by exploring the use of ERBITUX in additional tumor types including brain, breast, bladder, gastric, lung, pancreas and prostate