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GLG News by ONC-Avastin Prescribers for Colorectal Cancer (US)

Analysis of: More Prominence Urged for Heart Risks in Breast Cancer Treatment (www.medpagetoday.com)
The current understanding of heart risks from chemotherapy does not stop oncologists from giving chemotherapy for early breast cancer in those who need it. Better drugs for preventing relapse are certainly welcome, when they are developed.
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: Authorization For AGENDA Phase 3 Trial Of Genasense(R) In Advanced Melanoma Granted By French Regulatory Agency (www.medicalnewstoday.com)
The AGENDA trial is designed to determine whether the addition of Gensense to DTIC can impprove outcomes for melanoma patients as compared with DTIC alone.
Analysis of: Curis, Inc. Announces Initiation of Expansion Cohort in Collaborator Genentech's Phase I Clinical Trial of a Systemically Administered Hedgehog Antagonist (www.pipelinereview.com)
What are my thoughts?  Not much. This drug has just entered early phase studies and the most that we can make of it is that people can tolerate it.
Analysis of: US FDA approves Bristol-Myers breast cancer drug (www.reuters.com)
Ixempra is a new drug with big implications.
Analysis of: GSK receives approval for Hycamtin(R) (topotecan) capsules for the treatment of relapsed small cell lung cancer (www.pipelinereview.com)
- Hycamtin represents the first approved second line drug treatment for small cell lung cancer. - The oral preparation will avoid the need for intravenous lines and allow considerable flexibility in treating this disease. - Hycamtin will allow maintenance therapy for those patient who are unable...
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer (www.pipelinereview.com)
Pemetrexed, in combination with Cisplatin, represents an effective first line therapy for patients with NSCLC.  However, there is little to distinguish the activity of this regimen from that of other commonly used doublets and its major advantage may result from a more favorable toxicity profile. ...
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: FDA Approves Expanded Labeling for Campath® to Include First-line Treatment for Leading Form of Adult Leukemia (www.pipelinereview.com)
Alemtuzumab has received FDA approval for use in patients with previously untreated CLL.  This approval is based on a comparison with Chlorambucil, an agent not commonly used for first line treatment in the United States.  The toxicity profile of CAMPATH and the availability of other agents,...
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: DAHANCA Initiates Head and Neck Cancer Study with Genmab's HuMax-EGFr (www.pipelinereview.com)
Humax-EGFr is an antibody targeting the EGF receptor.  Currently, Cetuximab, another EGFr antibody is approved for the treatment of patients with unresectable head and neck cancer.   Humax-EGFr could have a role in this disease if its efficacy is greater than or its toxicity profile is...
Michael Grossbard, MD, Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Analysis of: US FDA panel to review Avastin for breast cancer (investing.reuters.co.uk)
At present,  no biologic agents have been approved for the treatment of her-2 negative breast cancer.  The addition of Avastin to chemotherapy for patients with stage IV breast cancer has the potential to improve progression free survival and improve quality of life.  FDA approval of...
Taral Patel, MD, Oncologist
Taral Patel, MD, Oncologist
Mid Ohio Oncology Hematology Inc.
August 29, 2007
CMS
Analysis of: New Medicare Regulations Adopted To Reduce Certain Hospital Infections And Medical Errors (www.medicalnewstoday.com)
CMS is doing right thing. This will aviod pt fall and bedsore during hospitalzation

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