The Expertise Imperative and Compliance Technology
Access to a diverse array of specialized expert inputs drives superior decisions in every organizational context: within corporations, by investors and consultancies, and within nonprofits. When decision makers are confident of their decision inputs, they can respond more quickly and creatively to challenges and opportunities.Learn more about GLG's Compliance Framework
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The ILLUMINATE trial DSMB stopped the study because of the adverse events, but until we have more details about those outcomes it is hard to know whether this signals the failure of the strategy as a class, or a specific complication of this drug. It is perfectly possible to imagine that though torcetrapib...
I wrote on 11/10/06 that "...A clinical trial demonstrating that torcetrapib (in combination with atorvastatin) does increase HDL levels is a first step. Can we imagine, though, that this effect might not have the expected result on coronary artery events? The cardiovascular literature is full of examples...
This study investigated carotid endarterectomy versus carotid stenting in patients with severe carotid stenosis. The study was stopped prematurely due to safety and futility. The 30-day incidence of stroke or death was 3.9% versus 9.6% for endarterectomy versus carotid stenting. This data implies that...
This is a general commentary regarding coronary stent thrombosis and highlights the difficulties which Medtronic (Endeavor), Abbott (Xience V and Conor Medsystem (CoStar) may soon face with FDA approval of their new stents which are currently unavailable in the US. It also highlights that drug-coated...
In a series of 15 patients, the Thoratec ventricular assist device was utilized with associated medical treatment for severe non-ischemic heart failure. Eleven of the fifteen patients recovered and avoided transplantation. Key implications include increased utilization of ventricular assist devices...