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GLG News by Non-Electrophysiologist Cardiologists (US)

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October 27, 2008
Medtronic Endeavour Failing to Live Up to Expectations
Analysis of: Medtronic Endeavor Heart Stent Tied to Complications | www.bloomberg.com
Author: GLG Expert Contributor
The Endeavour stent appears to have a higher restenosis rate than currently marketed Drug Eluting Stents without the improved safety profile claimed by the company.  This finding is at odds with the companies marketing message to cardiologists.  These studies, along with the introduction of...
August 6, 2008
Statin therapy for children
Analysis of: 8-Year-Olds on Statins? A New Plan Quickly Bites Back | www.nytimes.com
Author: GLG Expert Contributor
The  potential market for treatment of lipids(cholesterol)continues to grow. Recent recommendations regarding potential for treatment of children as young as 8 are controversial, primarily because of the lack of data to demonstrate efficacy in terms of "hard" endpoints(i.e. mortality/MI)vs. morbidity...
July 28, 2008
Economic Forces Leading to Use of More Generic Medications
Analysis of: Patients Curb Prescription Spending | online.wsj.com
Author: GLG Expert Contributor
Given the economic pressures on patients, they are now more likely to ask for generic medications than they were in the past.  Given that there are generic versions of several classes of medications, physicians such as me are more likely to comply with a patient's request for a generic than in...
June 23, 2008
Chinese Food For Prevention?
Analysis of: Study Finds Chinese Food Good For Your Heart | www.medicalnewstoday.com
Author: GLG Expert Contributor
Once again we are finding that traditional Chinese medicine is just as affective in this day and time as it was back during the Tang Dynasty.  Even then, Chinese red yeast rice was known to 'remove blockages' and aid in digestion.  What is even more exciting in this study,...
June 23, 2008
Doctors don't profit from EHRs
Analysis of: Most Doctors Aren’t Using Electronic Health Records | www.nytimes.com
Author: GLG Expert Contributor
Third party payers benefit the most from EHRs because it makes charts easier to audit   The cost of implementing an EHR is excessive for a small practice of 2-5 physicians.
May 28, 2008
Tekturna scripts
Analysis of: New data show Tekturna HCT® is twice as effective at reducing blood pressure than the diuretic HCT alone | www.novartis.com
Author: GLG Expert Contributor
I am a heavy user of ARB's and Tekturna.  This article does not really show anything of significance.  Most practicing physicians have seen much better results and much better tolerability with ARB's than diuretics. I do not think this is going to change prescribing habits of anyone. ...
May 27, 2008
Thrombus Aspiration in Acute MI
Analysis of: Medtronic Says Thrombus Aspiration Before Stenting Betters Survival Rates Of Myocardial Infarction Patients | www.rttnews.com
Author: GLG Expert Contributor
Mechanical thrombectomy of the coronary arteries has becoming increasingly more common with the advent of simpler aspiration catheters.  Although its use in the setting of acute myocardial infarction is even more common, it is not routine.  Randomized data indicating its effect on clinical...
May 27, 2008
Fixed doage of metoprolol utilized
Analysis of: Higher Risk of Death and Stroke in Patients Given Beta Blockers After Non-Cardiac Surgery (POISE Trial) | pharmalive.com
Author: GLG Expert Contributor
This is not a real life article. Physicians will titrate the dosage of beta blockers, not utilize a fixed dose. The AHA ACC guidelines still recommend beta blockers, but the guidelines do not specifiy a fixed dosage.
May 27, 2008
STEMI patients do better with clot aspiration prior to stenting
Analysis of: Medtronic Says Thrombus Aspiration Before Stenting Betters Survival Rates Of Myocardial Infarction Patients | www.rttnews.com
Author: GLG Expert Contributor
Acute myocardial infarction is caused by a clot in the artery that obstructs and quickly reduces blood flow to the artery. The best treatment for STEMI is rapid opening of the artery with angioplasty and stenting. The article is important since it shows that active removal of the clot prior to stenting...
May 19, 2008
Obvious answer - wrong question - NO IMPACT on prescribing
Analysis of: New data show Tekturna HCT® is twice as effective at reducing blood pressure than the diuretic HCT alone | www.novartis.com
Author: GLG Expert Contributor
It is well known that the addition of thiazide diuretic to ACEI or ARB treatment adds about 10 mm Hg reduction on top of the 10 mm Hg reduction provided by the ACEI or ARB agent.  It is expected that blocking renin in the renin angiotensin system with Tekturna would provide a similar result.

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