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GLG News by Niaspan Prescribers for Raising HDL

April 9, 2008
Slim Chance?!
Analysis of: Taranabant looks promising (www.taranabant-health.com)
Merck's endocannabinoid inverse agonist (CB1R )recently completed a 52 wk trial in which 2000 subjects were randomized to placebo, 2, 4, or 6 mg of taranabant.  Before the trial ended, the 6 mg dosed subjects had to be rerandomized to placebo or 4 mg due to toxicity.  The...
Carlos Dujovne, MD, Professor of Medicine and Director
Carlos Dujovne, MD, Professor of Medicine and Director
OREGON HEALTH & SCIENCE UNIVERSITY - CC
Analysis of: China Plant Played Role (online.wsj.com)
1:Most of our legislators are forcefully endorsing generic drug usage and importing cheaper drugs.2:As a physician specialist in Clinical Pharmacologist I am fully aware or the safety and efficacy pitfalls of poorly manufactured  drugs and have done clinical research documenting the risks of patients...
Analysis of: Diabetes Study Partially Halted After Deaths (www.nytimes.com)
That more people died in the "tight" control group is true, but was it tight control that was responsible or could it have been the means by which it was controlled?  It was not rosigitazone (Avandia) or hypoglycemia responsible for the deaths, according to the articles (the scientific article...
Analysis of: Denosumab Osteoporosis Study Met Primary and All Secondary Bone Mineral Density Endpoints in a Head-to-Head Comparison with Weekly Alendronate (FOSAMAX(R)) (www.pipelinereview.com)
After the many false hopes raised using surrogate markers, we certainly want to wait for definitive end-point trial results involving fracture rate and possible long-term side effects.  However the 40% greater increase in BMD compared to the standard of bisphosphonate therapy is quite exciting. ...
Analysis of: Operator of Walk-In Clinics Shuts 23 Located in Wal-Mart Stores (www.nytimes.com)
It is important to understand that geographic placement of these clinics is important.  I think these clinics will continue to pop up until the industry feels out exactly where the market is.  We are located in the southwest suburbs of Chicago, and there are many of these clinics which are...
Analysis of: 19 Percent of Office-Based Physicians Refuse to See Pharmaceutical, Biotech and Medical Device Sales Reps (www.drugs.com)
The time taken away from seeing patients is expensive.  The physicians do not feel like they are trained well enough in understanding scientific studies and so they may be biased by information provided by the representatives that is not scientific.  They believe that innovations by pharmaceutical...
Analysis of: Daiichi Sankyo, Lilly Submit New Drug Application for Investigational Antiplatelet Drug, Prasugrel, with U.S. Food and Drug Administration (www.pipelinereview.com)
TRITON-TIMI 38 study of 13,608 patients with ACS compared prasugrel against clopidogrel, combined with aspirin.  Prasugrel reduced the combined rate of CV death, MI or stroke (12.1% for clopidogrel vs. 9.9% for prasugrel). The benefit came at a cost of increased serious bleeding (1.4%, vs....
Analysis of: CDC: Too few adults get their vaccines (news.yahoo.com)
It is disappointing that Medicare does not pay for well exams where vaccines like this would be given.  It is unfortunate that in an attempt by medicare to save money, they are probably losing money.  It is at the annual well exam where I counsel patients on the vaccinations that they should...
Analysis of: Blue Cross proposes fix for uninsured Americans (news.yahoo.com)
I work as both an ER physician and a Family Physician in a clinic and something needs to be done so that I do not need to see patients in the ER for problems that could easily be handled in the less expensive clinic.  Other countries have better health plans because patients have an incentive to...
Carlos Dujovne, MD, Professor of Medicine and Director
Carlos Dujovne, MD, Professor of Medicine and Director
OREGON HEALTH & SCIENCE UNIVERSITY - CC
Analysis of: No right to experimental drugs for dying patients: Supreme Court (news.yahoo.com)
One, twenty years ago I was the chairman of the government affairs committee of the American Society for Clinical Pharmacology and Therapeutics; under that role my committee was successful lobbying for approval new investigational drugs for possible treatment of AIDS. We were successful in getting the...

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