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December 1, 2008
Designing effective medications for populations depends on how easy it is to diagnose the populations.
Analysis of: Personal medicine is goal of Eli Lilly & Co. | www.azcentral.com
Author: GLG Expert Contributor
The article indicates that medications will be designed to be effective for particular populations.  This will prevent the need to try medications which are effective for 50% of the population or less.
Carlos DujovneNovember 13, 2008
Crestor's results in the Jupiter Study likely to change medical-economic perspectives in statin choices.
Analysis of: CRESTOR Demonstrates Dramatic CV Risk Reduction in a Large Statin Outcomes Study | www.astrazeneca.com
Author: Carlos Dujovne, Professor of Medicine and Director, OREGON HEALTH & SCIENCE UNIVERSITY - CC
1:Crestor is the most potent statin in the market,yet is 3d in sales behind Zocor and Lipitor.2:The efficacy supriority together with its capacity to lower CRP levels led to the highest rate of ASCVD prevention in the shortest period of time evr documented in statin trials.3:The trial in near 18,000...
October 13, 2008
C. difficile not linked to antibiotics will change how I order stool studies
Analysis of: C. Difficile And Antibiotics Not Necessarily Linked, Study Finds | www.sciencedaily.com
Author: GLG Expert Contributor
C. difficile is only linked to antibiotic use about half the time.  In addition c. difficile can complicate IBS more that previously thought.  This may be why antibiotics that cover c. difficile have been useful in treating irritable bowel syndrome.  
October 6, 2008
Clinical Trials Go Unpublished
Analysis of: Many Trial Reports on FDA-Approved Drugs Go Unpublished | www.washingtonpost.com
Author: GLG Expert Contributor
The articles more often go unpublished if the study indicates that there is no benefit to new drugs over older drugs.
October 3, 2008
Heart attack and Cardiovascular disease increased with anticholinergics
Analysis of: COPD Medicines: Risky or Safe? | www.webmd.com
Author: GLG Expert Contributor
How can we best determine if the correlation is a direct cause an effect.  Do the anticholinergics cause increase MI and cardiac disease or do the anticholinergics lead to something else that results in MI and carddiovascular disease.
October 3, 2008
ADHD parent training programs will not likely be effective in the US
Analysis of: Parents 'need lessons about ADHD | news.bbc.co.uk
Author: GLG Expert Contributor
The article summarizes the best treatment for ADHD in children; training the parents and teachers how to more effectively interact with the child.  The article is written for the BBC.
Carlos DujovneSeptember 29, 2008
Mutiple causes for no publications of many reports on FDA approved drugs.Some problems and solutions.
Analysis of: Many Trial Reports on FDA-Approved Drugs Go Unpublished | www.washingtonpost.com
Author: Carlos Dujovne, Professor of Medicine and Director, OREGON HEALTH & SCIENCE UNIVERSITY - CC
This article is not news for clinical researchers like myself that have performed hundreds of clinical trials in collaboration with the Pharmaceutical Industry. Some of the most common reasons for that are: A)Negative studies are difficult to get published.B)Negative results for the dug of the...
September 15, 2008
Another reason why government intervention doesn't work
Analysis of: Medicare overpaid on drugs with new generics, report says | www.latimes.com
Author: GLG Expert Contributor
The Medicare drug system was a political ploy. This just confrims it. The private insurers were unwilling to offer Rx coverage before then because they understood the economics of it.
August 11, 2008
Byetta Preventing Mortality? Even IF True, Wrong Formulation?
Analysis of: Lilly Diabetes Drug Shows a Life-Extending Promise | www.nytimes.com
Author: GLG Expert Contributor
The recent finding that Byetta therapy decreased mortality in the ACCORD study needs to be replicated in studies designed to address that point.  Even if it is replicated and statistically significant, it probably will not be true for the widely anticipated once weekly extended formulation...
August 6, 2008
Statin therapy for children
Analysis of: 8-Year-Olds on Statins? A New Plan Quickly Bites Back | www.nytimes.com
Author: GLG Expert Contributor
The  potential market for treatment of lipids(cholesterol)continues to grow. Recent recommendations regarding potential for treatment of children as young as 8 are controversial, primarily because of the lack of data to demonstrate efficacy in terms of "hard" endpoints(i.e. mortality/MI)vs. morbidity...

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