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It is well known that the addition of thiazide diuretic to ACEI or ARB treatment adds about 10 mm Hg reduction on top of the 10 mm Hg reduction provided by the ACEI or ARB agent. It is expected that blocking renin in the renin angiotensin system with Tekturna would provide a similar result.
TRITON-TIMI 38 study of 13,608 patients with ACS compared prasugrel against clopidogrel, combined with aspirin. Prasugrel reduced the combined rate of CV death, MI or stroke (12.1% for clopidogrel vs. 9.9% for prasugrel).
The benefit came at a cost of increased serious bleeding (1.4%, vs....
The Supreme Court has rejected the use of experimental drugs by the dying patients on the grounds that "The framers (of the US constitution) understood that the pursuit of life is an inalienable right that should not be abridged without due process of law." Over the years our patients with terminal...
Physicians have several possible conclusions that can be taken; These include:
- the trial is flawed - the selection of patients with much less CIMT than previous trials such as ASAP and ARBITER flaws the study
- the failure to meet the trial endpoint is only a surrogate and clinical trial data...
By restoring function in the late Na channel and hence improving diastolic function (amongst other things), Ranexa has worked terrifically in my patients with any evidence for diastolic dysfunction. This typically manifests with shortness of breath and can be associated with an elevated level...
The fewer the injections, the more market share if all else is the same. We will await to see how needle size will affect LAR acceptance. My estimate is that it will absolutely not. Patients never asked what the size of the needle was prior to initiation of BYETTA bid--they just heard "weight loss and...