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GLG News by Nexavar Prescribers: Oncologists

Eric Whitman, MD, Medical Director, Office of Grants and Research
Eric Whitman, MD, Medical Director, Office of Grants and Research
Atlantic Health System Inc
Analysis of: Digital Diagnosis: New Tool for Detecting Skin Cancer (www.ehponline.org)
Melafind is currently undergoing Phase III testing. If these results are positive (and I cannot comment on the trial since I do not know any of the details) then presumably the device will be approved. If practitioners cannot be reimbursed for its use by insurance companies, it will be difficult...
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Hospital-borne ailments face Medicare budget ax (www.indystar.com)
CMS has ecome very aggressive about denying coverage of so called negative impact therapy What is the real motive behind the CMS debate and various therapies? Cancer care has seen this time and time again.
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma (bloodjournal.hematologylibrary.org)
zanolimumab (HuMax-CD4) will contribute significantly to CTCL therapy zanolimumab (HuMax-CD4) has much potential in the market share
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: GlaxoSmithKline Announces Swiss Approval Of Tyverb®, A New Oral Treatment For Advanced Breast Cancer (www.medicalnewstoday.com)
Is Lapatinib a major accomplishment for GSK? Was the recent phase III that led to approval understood? Are there threats to Lapatinib in the near furure?
Eric Whitman, MD, Medical Director, Office of Grants and Research
Eric Whitman, MD, Medical Director, Office of Grants and Research
Atlantic Health System Inc
Analysis of: Panel Endorses New Anti-Tumor Treatment (www.therapeuticsdaily.com)
Provenge was shot down by the FDA this month. This active specific immunotherapy for advanced prostate cancer failed to reach any of its primary or secondary endpoints. The survival "benefit" touted in the lay press is likely a statistical anomaly but a large scale study is pending (if the company ...
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Randomized Phase III Trial Showed ERBITUX Improved Secondary Endpoints Of Progression-Free Survival And Disease Control In Colorectal Cancer Patients (www.medicalnewstoday.com)
The EPIC trail was negative The trial will negatively effect erbitux in CR ( colorectal) re others trials to focus on with Erbitux
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Exelixis Announces First Quarter 2007 Financial Results and Business Update (ir.exelixis.com)
There is new biopharm company Exelixis that is putting a large amount of effort in developing a variety of small molecule TKI's TKI's are becoming a crowded area of anti cancer development
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: "PET/CT in Cancer Patient Management" Examined in Journal of Nuclear Medicine Supplement (interactive.snm.org)
PET scans have become a major tool in oncologyPET scans have endless potential in applications to managing cancer patientsPET scans are "easier said than done" in regards to third party payorsPET scan are over used?
Donald Fleming, MD, Division Head of Hematology and Oncology
Donald Fleming, MD, Division Head of Hematology and Oncology
Davis Health System, Inc.
Analysis of: Positive Results Prompt US National Cancer Institute To Make Gleevec(R) Available To Patients In Post-Surgical GIST Study (www.medicalnewstoday.com)
The most successful treatment for GIST has demonstrated a benefit in the adjuvant settingThe use of Gleevec in this setting while a major accomplishment for any anti-tumor therapy, will have a modest impact on sales of Gleevec
Analysis of: Pharmacyclics Announces FDA Filing of New Drug Application for Xcytrin(R) Injection to Treat Lung Cancer Brain Metastases (www.pipelinereview.com)
Xcytrin (motexafin gadolinium) is a rationally designed compound that concentrates selectively in cancer cells, inducing redox stress and triggering apoptosis (cell suicide). Xcytrin has been shown to be synergistic with radiation and in the pivotal phase III SMART trial was shown to improve the...

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