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GLG News by Neurologists who Treat Neuromuscular Disorders (US)

February 21, 2008
More than just AVASTIN
Analysis of: Genentech has billions at stake in FDA battle (sanfrancisco.bizjournals.com)
Genentech will have more battles to fight in the future aside from Avastin.  This medication appears extremely promising for the treatment of breast cancer, however, physicians are still mixed in their opinions about its place in the treatment of breast cancer.
Analysis of: China Plant Played Role (online.wsj.com)
The trend to utilize raw materials manufacturers outside the US is driven by dramatic cost savings and is certainly still rising.  Chemistry controls should be specifically targeted to identify impurity profiles in the receipt and release testing of imported material.  FDA could become more...
February 15, 2008
Gamunex in CIDP
Analysis of: Positive Results from Phase III Trial of Gamunex in Patients with CIDP (pharmalive.com)
IVIg (intraveonus immunoglobulin) reduces disability and reduces risk of relapse in patients with CIDP (chronic inflammatory demyelinating polyradiculoneuropathy).
Daniel Wynn, MD, Director, Clinical Research
Daniel Wynn, MD, Director, Clinical Research
Consultants In Neurology Ltd.
Analysis of: Positive Results from Phase III Trial of Gamunex in Patients with CIDP (pharmalive.com)
Talecris' form of IVIG, Gamunex was studied in the largest trial of IVIG in chronic inflammatory polyradiculoneuropathy (CIDP), with more than twice as many patients moving into remission.  CIDP is a common acquired autoimmune peripheral neuropathy, which if not treated, may lead to a peripheral...
Analysis of: AP IMPACT: FDA faults drug plants (seattlepi.nwsource.com)
Quality is critical in human pharmaceutical processes from research and development through to manufacturing and commercialization of pharmaceuticals for human consumption. Slippage in quality norms may reflect an underlying shift in culture within an organization.  FDA compliance and inspectional...
Daniel Wynn, MD, Director, Clinical Research
Daniel Wynn, MD, Director, Clinical Research
Consultants In Neurology Ltd.
Analysis of: Somaxon Pharmaceuticals Submits New Drug Application For SILENOR(TM) For The Treatment Of Insomnia (www.pipelinereview.com)
Somaxon Pharmaceuticals has submitted a NDA for Silenor for the treatment of insomnia.  The active ingredient is doxepin, which has been available for years.The effect of the drug can be expected to be very modest, side effects unfavorable when compared to Ambien or Lunesta, and with both significant...
Analysis of: Artificial Disc Versus Fusion: A Prospective, Randomized Study With 2-Year Follow-up on 99 Patients (www.medscape.com)
Outcomes in patients implanted with the artificial disc compare favorably with single level ACDF after 2 years.
Daniel Wynn, MD, Director, Clinical Research
Daniel Wynn, MD, Director, Clinical Research
Consultants In Neurology Ltd.
Analysis of: GlaxoSmithKline and XenoPort report positive top-line results of second phase 3 restless legs syndrome trial for XP13512/GSK1838262 (www.pipelinereview.com)
Xenoport's trial for XP13512 in restless legs syndrome (RLS) shows strongly positive 9 month data in second phase 3  trial, should be a major win in the marketplace.  RLS represent a major unmet need, for drugs with sustained efficacy and high tolerability.
Analysis of: UCB Announces FDA Filing for lacosamide in the Treatment of Partial Onset Seizures (www.reuters.com)
UCB has filed new drug application for regulatory approval for lacosamide through FDA and European Medicines Agency.  Primary indication would be the treatment of partial onset seizures (epilepsy)
Analysis of: Elan Mulls Options for MS Drug Tysabri (www.smartmoney.com)
Mush of Elan's future will depend on the efficient and reasonable marketing of Tysabri.  The fact that more than 33,000 patients now have been treated worldwide without any new cases of PML favors Elan's success.

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