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GLG News by Neurologists who Treat Epilepsy (US)

Daniel Wynn, MD, Director, Clinical Research
Daniel Wynn, MD, Director, Clinical Research
Consultants In Neurology Ltd.
Analysis of: Somaxon Pharmaceuticals Submits New Drug Application For SILENOR(TM) For The Treatment Of Insomnia (www.pipelinereview.com)
Somaxon Pharmaceuticals has submitted a NDA for Silenor for the treatment of insomnia.  The active ingredient is doxepin, which has been available for years.The effect of the drug can be expected to be very modest, side effects unfavorable when compared to Ambien or Lunesta, and with both significant...
Analysis of: 19 Percent of Office-Based Physicians Refuse to See Pharmaceutical, Biotech and Medical Device Sales Reps (www.drugs.com)
What is the best way to market pharmaceutical and other medical products to physicians? There is certainly bias among some physicians against the pharmaceutical industry. It is felt by many that industry sponsored research studies are invalid and will always show the products in a favorable light. On...
Analysis of: Artificial Disc Versus Fusion: A Prospective, Randomized Study With 2-Year Follow-up on 99 Patients (www.medscape.com)
Outcomes in patients implanted with the artificial disc compare favorably with single level ACDF after 2 years.
Analysis of: CeNeRx BioPharma Announces Successful Completion of Phase l Clinical Program for Novel Antidepressant Agent Tyrima(TM) (www.pipelinereview.com)
I feel that this drug could make a major impact on treatment of depression due to it unique mechanism of action eg increasing all three neurotransmitters without the old side effects of MAOI.
Daniel Wynn, MD, Director, Clinical Research
Daniel Wynn, MD, Director, Clinical Research
Consultants In Neurology Ltd.
Analysis of: GlaxoSmithKline and XenoPort report positive top-line results of second phase 3 restless legs syndrome trial for XP13512/GSK1838262 (www.pipelinereview.com)
Xenoport's trial for XP13512 in restless legs syndrome (RLS) shows strongly positive 9 month data in second phase 3  trial, should be a major win in the marketplace.  RLS represent a major unmet need, for drugs with sustained efficacy and high tolerability.
Analysis of: U.S. Federal Court Issues Permanent Injunction Against Medtronic's Vertex And Vertex Max Screws (www.medicalnewstoday.com)
the use of Vertex polyaxial screws is only a minor part of the spinal implant protfolio at Medtronic (MDT:NYSE).  This should not affect the bottom line to any significant extent.
Analysis of: Ceregene Presents Long-Term Follow-Up from Phase 1 Trial of CERE-120 in Parkinson's Disease (www.pipelinereview.com)
This is a very significant event for Ceregene.  Previous studies, with drug treatment, on treatment for parkinsons have shown that the placebo effect only lasts for three months.  The symptoms of Parkinson's  increase 5-10% per year( as part of the natural progression of the disorder). ...
Analysis of: Ceregene Presents Long-Term Follow-Up from Phase 1 Trial of CERE-120 in Parkinson's Disease (www.pipelinereview.com)
It is exciting to hear about the effectiveness of CERE-120 in advanced Parkinson's disease.
Analysis of: UCB Announces FDA Filing for lacosamide in the Treatment of Partial Onset Seizures (www.reuters.com)
UCB has filed new drug application for regulatory approval for lacosamide through FDA and European Medicines Agency.  Primary indication would be the treatment of partial onset seizures (epilepsy)
Analysis of: Seroquel XR Receives Approval From FDA for Maintenance Treatment of Schizophrenia (pharmalive.com)
I believe this will only enhance our arenal for the treament of schizophrenia and bipolar disorder in that the long acting version will enhance compliance and maintain better levels of the drug in patients.

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