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GLG News by Multiple Myeloma Physicians

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April 1, 2008
Reliable diagnosis of RSV infection could be a major improvment for immunecompromises patients
Analysis of: Molecular Testing for Respiratory Viruses | www.aacc.org
Author: GLG Expert Contributor
RSV infection is very difficult to confirm. In my hospital we use molecular determination of RSV genome from nasal secretions. This approach is expensive, time consuming and it does not offer a quick diagnosis. We treat mainly onco-hematological patients, who are at high risk of RSV infection. In the...
April 1, 2008
Implications of mechanism's of action? Who cares if it works!
Analysis of: OXiGENE Begins Phase II NSCLC Trial of ZYBRESTAT(TM) in Combination with Bevacizumab and Chemotherapy | www.pipelinereview.com
Author: GLG Expert Contributor
OXiGENE, Inc's., ZYBRESTAT(TM) (fosbretabulin), a vascular disrupting agent (?) is being given with Taxol/Carboplatin (T/C) in a randomized Phase II study. Soooo T/C with or without ZYBRESTAT.
March 31, 2008
Well at least they have Procrit (Whoops!)
Analysis of: Cancer risk seen with J&J foot gel: FDA | uk.reuters.com
Author: GLG Expert Contributor
 "A Johnson & Johnson foot gel used by diabetics may increase the risk of cancer and death, U.S. health officials said on Thursday in announcing an investigation into the issue."
March 31, 2008
New Therapy for Hormone Refractory Prostate CA. Maybe!!!
Analysis of: Oxford BioMedica Report Encouraging New Phase II Trial Results With TroVax(R) in Prostate Cancer | www.pipelinereview.com
Author: GLG Expert Contributor
Phase II results ++
March 31, 2008
Immunoconjugates Are Better in Theory Than Practice
Analysis of: Immunomedics Develops New Immunoconjugates for Targeted Chemotherapy of Pancreatic and Other Cancers | www.pipelinereview.com
Author: Michael Grossbard, Professor of Clinical Medicine, Columbia University College of Physicians and Surgeons
Immunomedics has developed three new immunoconjugates between monoclonal antibodies and SN-38 i an effort to target colon, pancreas and lung cancer.  Preclinical data are effective in a metastatic colon cancer model but there are no clinical data.
March 28, 2008
Can I eat until my IQ drops to 120.......?
Analysis of: Study Ties Belly Fat to Dementia | online.wsj.com
Author: GLG Expert Contributor
"Belly Fat" in middle age can be associated with the development of dementia as one ages.
March 27, 2008
New kind of monoclonal antibodies mean better results?
Analysis of: Immunomedics Develops New Immunoconjugates for Targeted Chemotherapy of Pancreatic and Other Cancers | www.pipelinereview.com
Author: GLG Expert Contributor
The use of immunoconjugates in the development of monoclonal antibodies has been long tested with toxins but not with pro-drugs
March 27, 2008
CT scanning to detect early lung cancers? Flawed due to ethical concerns
Analysis of: Cigarette Company Paid for Lung Cancer Study | www.nytimes.com
Author: GLG Expert Contributor
Support from a cigarette manufacturer raises questions as to the conclusions from this study which says early detection by repetitive CT's can improve cancer cure rates by early detection. (making smoking safer?)
March 25, 2008
Overuse of Lupron & Zoladex in "early" Prostate Carcinoma?
Analysis of: Prostate-Cancer Treatment Questioned | online.wsj.com
Author: GLG Expert Contributor
Hormone blocking therapy is added to radiation, unnecessarily, in early prostate cancer patients. The result in early stage patients is unnecessary side effects and reduced quality of life. Go figure.
March 25, 2008
Confirmation Trial is Needed
Analysis of: Vermillion Announces Positive Results From Clinical Trial of Ovarian Tumor Triage Test; Study Meets Primary Endpoints | www.pipelinereview.com
Author: GLG Expert Contributor
Early detection of ovarian cancer is of paramount importance

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