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GLG News by Lung Cancer Oncologists (US)

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September 19, 2008
I know, I know there is no money in diagnostics but....
Analysis of: Raising the Profile of Cancer of Unknown Primary | jco.ascopubs.org
Author: GLG Expert Contributor
RNA gene profiling will allow up to get a better handle on the primary site, especially with increasing targeting opportunities in many neoplasms.
September 18, 2008
"Star Wars" technology interfaces with radiation oncology
Analysis of: Proton Radiotherapy: A Review | www.nytimes.com
Author: GLG Expert Contributor
Proton beam therapy will effect the market place and force competition for oncology centers to get "the next best thing."
September 9, 2008
Velcade 1st line? No surprise.....
Analysis of: Velcade (Black Triangle Drug) (bortezomib) Approved For Previously Untreated Multiple Myeloma | www.therapeuticsdaily.com
Author: GLG Expert Contributor
Velcade, given with Melphalan & Prednisone approved for use 1st line in non-transplant myeloma patients first line.
September 9, 2008
IT'S ALIVE!!?? Astra Zeneca's (AZ) Iressa (At least in Japan)
Analysis of: Gefitinib Versus Vinorelbine in Chemotherapy-Naïve Elderly Patients With Advanced Non–Small-Cell Lung Cancer (INVITE): A Randomized, Phase II Study | jco.ascopubs.org
Author: GLG Expert Contributor
2 separate studies show that: 1. "...there was no statistically significant difference in overall survival....for gefitinib compared with docetaxel. Gefitinib remains an effective treatment option for previously treated Japanese patients with NSCLC." http://jco.ascopubs.org/cgi/content/full/26/26/4244...
September 8, 2008
Think about the future and what this will lead to....
Analysis of: In Long-Awaited Maps of Cancer, The Breakthrough Is the Problem | online.wsj.com
Author: GLG Expert Contributor
Pharmacogenomics will lead to the development of targeting agents and offer true hope for the future.
September 2, 2008
GIST: So what else is new.....
Analysis of: Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery | www.therapeuticsdaily.com
Author: GLG Expert Contributor
Novartis is looking for approval for therapy in C-KIT + Gastrointestinal stromal tumors
August 29, 2008
Bcl-2 apoptosis inhibition: The next "best" thing?
Analysis of: Expanding Circle of Inhibition: Small-Molecule Inhibitors of Bcl-2 as Anticancer Cell and Antiangiogenic Agents | jco.ascopubs.org
Author: GLG Expert Contributor
Bcl-2 inhibition by small molecules stands to be the next avenue for antineoplastic therapy- Looks like the real deal!
August 29, 2008
So Much for GVAX.... for now?
Analysis of: Cell Genesys Ends Clinical Trials For Prostate Cancer Treatment | online.wsj.com
Author: GLG Expert Contributor
No reason for the increased mortality vs Chemo alone was identified. Cell Genesys is looking into where to go now.
August 29, 2008
Velcade in myeloma 1st line. Am I s?urprised
Analysis of: Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma | content.nejm.org
Author: GLG Expert Contributor
Velcade + classic Melphalan/ Prednisone  (MP) is better than MP alone. No surprise
August 25, 2008
Amgen's long awaited product to treat chronic ITP will be well receive.
Analysis of: Amgen Blood-Disorder Drug Gains Clearance | online.wsj.com
Author: GLG Expert Contributor
Chronic ITP is not all that uncommon and becomes a quality of life issue with chronic steroid use as well as agents that are normaly used in neoplasia and even derivatives of male hormones.

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