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GLG News by Lung Cancer Oncologists (US)

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February 25, 2008
Avastin Approved in Breast Cancer: the correct thing was done
Analysis of: Genentech Clears Hurdle On Cancer Drug Avastin | online.wsj.com
Author: GLG Expert Contributor
Avastin will be used in the therapy of "advanced" metastatic breast cancer, despite controversial data. In a disease with multiple options and a variable course it is virtually impossible to prove improved survival!!
February 22, 2008
Nexavar (Onyx & Bayer): down & out???
Analysis of: Onyx's Double Dose of Trouble | www.fool.com
Author: GLG Expert Contributor
The Nexavar lung cancer trial was terminated by the data monitoring committee PLUS it caused increased deaths in the squamous cell subgroup. Future in lung cancer?? PLUS: recent info also has shown cardiac events in Nexavar making it a potential loser in the race for kidney cancer dollar.
February 21, 2008
Treanda: A winner for Cephalon in Low grade non-Hodgkin's lymphoma (NHL) AND chronic lymphatic leukemia (CLL).
Analysis of: FDA Accepts TREANDA(R) New Drug Application for the Treatment of Relapsed Indolent Non-Hodgkin's Lymphoma | www.pipelinereview.com
Author: GLG Expert Contributor
The FDA will be deciding on Treanda in CLL next month and with a litttle luck NHL in the fall of this year
February 21, 2008
Avastin (Genentech): Approval in breast cancer? It would be the correct thing to do!
Analysis of: Genentech has billions at stake in FDA battle | sanfrancisco.bizjournals.com
Author: GLG Expert Contributor
Genentech has it's fingers crossed Re: approval or rejection of Avastin in breast cancer. If rejected it will lose it's compendia listing also adversely effecting insurance reimbursement.
February 20, 2008
Picoplatin (Poniard) in Metastatic Prostate Cancer: Why not?
Analysis of: Poniard Pharmaceuticals Announces Positive First-line Phase 1 Safety and Efficacy Data With Picoplatin in Metastatic Prostate Cancer Patients | www.pipelinereview.com
Author: GLG Expert Contributor
Picoplatin + Taxotere (Sanofi) appears in a Phase I trial, to be better than Taxotere alone in reducing PSA levels in metastatic prostate cancer (MPCA.)      (Comparing historical, not head to head data)
February 20, 2008
GVAX (Cell Genesys) In Metastatic Prostate Carcinoma (MPCA). I'm Impressed So Far!
Analysis of: Cell Genesys Reports Association Between Immune Response and Patient Survival in Phase 2 Trial of GVAX Immunotherapy for Prostate Cancer | www.pipelinereview.com
Author: GLG Expert Contributor
Immunologic response translated into improved survivals in 1/2 of the trial subjects!
February 19, 2008
While Baxter and APP "fiddle" GSK's Lovenox should jump into the void
Analysis of: Baxter Rival APP Steps In Quickly To Supply Heparin | online.wsj.com
Author: GLG Expert Contributor
APP wants to jump into the void created by Baxter's "allergic" problems related to Chinese suppliers. BUT APP appears to also obtain some of it's product from China and with FDA's scrutiny I would not bet on continued supplies.
Taral PatelFebruary 19, 2008
Avastin In Breast cancer
Analysis of: In Second Trial, Avastin Is Found Effective in Treating Breast Cancer | www.nytimes.com
Author: Taral Patel, Oncologist, Mid Ohio Oncology Hematology Inc.
New data with low and high dose of Avastin with Taxoter
Taral PatelFebruary 19, 2008
improve Overall survival in prostate cancer
Analysis of: Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival | www.pipelinereview.com
Author: Taral Patel, Oncologist, Mid Ohio Oncology Hematology Inc.
esults showed that PROVENGE patients experienced improved survival if they received more cells across the three doses of PROVENGE (higher cumulative TNC count (p=0.019)) or higher cumulative CD54 upregulation values (p=0.009). The effect on survival for TNCs appeared to reflect in part the patients'...
February 18, 2008
Sutent (Pfizer) causes heart failure?? Advantage Nexavar (Bayer/Onyx) and Torisel (Wyeth)
Analysis of: Kidney Cancer Drug Linked to Higher Rate of Heart Problems | www.washingtonpost.com
Author: GLG Expert Contributor
Sutent is associated with cardiac dysfunction!?

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