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GLG News by Lunesta Prescribers (US)

Analysis of: Personal medicine is goal of Eli Lilly & Co. (www.azcentral.com)
The article indicates that medications will be designed to be effective for particular populations.  This will prevent the need to try medications which are effective for 50% of the population or less.
Analysis of: Gardasil, Merck's Cervical Cancer Vaccine, Demonstrated Efficacy in Preventing HPV-Related Disease in Males in Phase III Study (www.fiercebiotech.com)
This study reveals the nature of the disease- it affects both men and women.   This study confirms the benefit of use of Gardasil in boys and men.   
Daniel Wynn, MD, Director, Clinical Research
Daniel Wynn, MD, Director, Clinical Research
Consultants In Neurology Ltd.
Analysis of: FDA Asks if Pain Pill Is Tamper-Proof (online.wsj.com)
Abuse resistant long acting narcotics offer benefit as they are less desirable to those who might wish a quick high via snorting, injecting crushed time-release narcotic. Unfortunately, given the higher cost than long acting generics and increased pressure on physicians to prescribe generics, expect...
Analysis of: Autism linked with rainfall in study (www.boston.com)
A recent article links autism to climate, specifically correlating diagnosis to rainfall. 
Louis Sanfilippo, MD, President
Louis Sanfilippo, MD, President
LCS Group, LLC
Analysis of: AstraZeneca Announces European SEROQUEL XR Submission for the Treatment of Generalised Anxiety Disorder (www.pharmalive.com)
Astra Zeneca is pursuing important medical and, of course, commercial goals by seeking the expanded clinical indications of major depression and generalized anxiety disorder for Seroquel XR, heir to blockbuster Seroquel (quetiapine).  This latest EU submission culminates regulatory submissions...
Analysis of: C. Difficile And Antibiotics Not Necessarily Linked, Study Finds (www.sciencedaily.com)
C. difficile is only linked to antibiotic use about half the time.  In addition c. difficile can complicate IBS more that previously thought.  This may be why antibiotics that cover c. difficile have been useful in treating irritable bowel syndrome.  
Analysis of: Many Trial Reports on FDA-Approved Drugs Go Unpublished (www.washingtonpost.com)
The articles more often go unpublished if the study indicates that there is no benefit to new drugs over older drugs.
Analysis of: COPD Medicines: Risky or Safe? (www.webmd.com)
How can we best determine if the correlation is a direct cause an effect.  Do the anticholinergics cause increase MI and cardiac disease or do the anticholinergics lead to something else that results in MI and carddiovascular disease.
Analysis of: Parents 'need lessons about ADHD (news.bbc.co.uk)
The article summarizes the best treatment for ADHD in children; training the parents and teachers how to more effectively interact with the child.  The article is written for the BBC.
September 2, 2008
Byetta Saves Lives
Analysis of: FDA Alert: Hemorrhagic or Necrotizing Pancreatitis in Patients Taking Byetta (www.fda.gov)
1.Hypertriglyceridemia causes pancreatitis 2.Most PCP, endocrinologists, and cardiologists are not effectively treating high triglycerides, and may make it worse by recommending a low fat = high carb diet 3.Accord data with 75% reduction in death, and patients desparate for wt loss will continue to...

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