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GLG News by Lexapro Prescribers: Psychiatrists (US)

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July 12, 2007
More of the same with a twist
Analysis of: INVEGA(TM) Receives Marketing Authorization In European Union For Treatment Of Schizophrenia | www.pipelinereview.com
Author: GLG Expert Contributor
1. Need for active comparator clinical trials, e.g, comparing medication not just to placebo but to risperidone and olanzapine acutely and short-term 2. Advantages of extended release preparations include less daily fluctuation in in drug concentration (peak to trough) so patients may spend more time...
July 12, 2007
Alzheimer's Drug Patch Important Advance
Analysis of: UPDATE: Novartis Wins FDA OK For Alzheimer's Drug Patch | money.cnn.com
Author: GLG Expert Contributor
1. Will faciltiate compliance and administration of medication 2. May have fewer drug-drug interactions 3. History for other conditions, e.g, hypertension (clonidine), ADHD (Daytrona) suggests value
July 12, 2007
Once daily Welbutrin XL represents a significant advance
Analysis of: Once-daily Wellbutrin XL | www.ncbi.nlm.nih.gov
Author: GLG Expert Contributor
1. XL preparation better tolerated  2. Facilitates better compliance and adherence to treatment than twice daily medication 3. Able to give higher dose early, better compliance likely result in fewer side effects, more rapid onset of antidepressant effect
July 9, 2007
Fighting Back Against The Third Party Practice of Medicine
Analysis of: British Pharmas Go to Court to Stop Drug Switching | www.therapeuticsdaily.com
Author: GLG Expert Contributor
Finally a group of medical professionals is stepping up to an important issue, indiscriminiate switching of patients to generic medications.  This issue is very important for a number of reasons, some not so immediately obvious.
July 5, 2007
Antidepressants and Pregnancy: Difficult Choices
Analysis of: Antidepressants and Pregnancy: New Findings | online.wsj.com
Author: GLG Expert Contributor
Recent data suggests that SSRI's are relatively safe in pregnancy.  Yet there are some probable associations...especially between three specific birth defects and SSRI's.
July 5, 2007
Once Daily Dosing About Patients--Not Just Patents
Analysis of: Once-daily Wellbutrin XL | www.ncbi.nlm.nih.gov
Author: GLG Expert Contributor
Skepticism often abounds when old drugs get new patent life by seemingly minor modifications...e.g. extended release formulations.  But there may be more benefit than clinicians often realize.
July 5, 2007
Depression and Brain Effects: "Pseudodementia" May Not be "Pseudo"
Analysis of: How Depression Weakens the Brain | online.wsj.com
Author: GLG Expert Contributor
If Depression increases risk for other brain disorders, such as dementia, this creates even more urgency for treatment.  It also potentially expands the market for antidepressant medication.
July 5, 2007
INVEGA - Two Innovations in One Pill
Analysis of: INVEGA(TM) Receives Marketing Authorization In European Union For Treatment Of Schizophrenia | www.pipelinereview.com
Author: GLG Expert Contributor
Invega is perhaps more than just a patent extender since it incorporates two innovations which represent a refinement to its parent compound.
June 28, 2007
Vyvanse-an important new medication but not the holy grail for ADHD
Analysis of: Shire showcases new drug Vyvanse to wary doctors | investing.reuters.co.uk
Author: GLG Expert Contributor
1.  While 70% of patients respond to available ADHD treatments, 30% do not so need for new treatments important 2. Lowering risk of abuse very important and attractive 3. Since same category of drugs as other stimulants not likely to appeal to clinicians who prefer prescribing non-stimulant,...
June 28, 2007
Retail Clinics: Unstoppable and Harbinger of a Broader Trend
Analysis of: Doctors, retailers square off | www.chicagotribune.com
Author: GLG Expert Contributor
It is perhaps laudable that the AMA wishes to prevent abuse of medical care and conflict of interest as the country (and word?) embrace retail clinics.  However, this is perhaps a necessary hiccup as the delivery of medical care evolves at an increasingly rapid pace driven by a multitude of fa...

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