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Daniel WynnJune 5, 2008
Novartis and Multiple Sclerosis: A Major Commitment
Analysis of: Extavia® approved in E.U for treatment of multiple sclerosis, first in planned portfolio of therapies from Novartis | www.asia-manufacturing.com
Author: Daniel Wynn, Director, Clinical Research, Consultants In Neurology Ltd.
Extavia, Novartis' brand of  interferon beta 1b, has been approved for the  treatment of multiple sclerosis by the European Union.  With FTY72, Fingolimod, Novartis has the eye on filing NDA by the end of 2009.  While essentially identical to Bayer's Betaferon interferon beta 1b,...
Daniel WynnJune 2, 2008
Abbott's ABT-089 --Much More than a Treatment for ADHD
Analysis of: Abbott Scientists Present A New Approach for Treating Attention-Deficit Hyperactivity Disorder | biz.yahoo.com
Author: Daniel Wynn, Director, Clinical Research, Consultants In Neurology Ltd.
The data on ABT-089 in adults has been released with positive results, whereas the adolescent/childhood trial is on-going for this novel compound for ADHD.  The key difference is the potential to improve learning, not simply regain attention and lessen hyperactivity.
Daniel WynnApril 24, 2008
COPAXONE from the START of MS
Analysis of: Teva Seeks Approval for the Extension of its Indication to Include the Treatment of Patients with a First Clinical Event Suggestive of MS | www.pipelinereview.com
Author: Daniel Wynn, Director, Clinical Research, Consultants In Neurology Ltd.
Copaxone has become the leading treatment for relapsing remitting MS in the US.  The results of the PRECISE trial will likely add to TEVA's sales momentum and boost sales further.
Daniel WynnFebruary 15, 2008
Win for Talecris' Gamunex IVIG in Inflammatory Polyneuropathy
Analysis of: Positive Results from Phase III Trial of Gamunex in Patients with CIDP | pharmalive.com
Author: Daniel Wynn, Director, Clinical Research, Consultants In Neurology Ltd.
Talecris' form of IVIG, Gamunex was studied in the largest trial of IVIG in chronic inflammatory polyradiculoneuropathy (CIDP), with more than twice as many patients moving into remission.  CIDP is a common acquired autoimmune peripheral neuropathy, which if not treated, may lead to a peripheral...
Daniel WynnFebruary 4, 2008
SILENOR -- A Sleeper among Hypnotics
Analysis of: Somaxon Pharmaceuticals Submits New Drug Application For SILENOR(TM) For The Treatment Of Insomnia | www.pipelinereview.com
Author: Daniel Wynn, Director, Clinical Research, Consultants In Neurology Ltd.
Somaxon Pharmaceuticals has submitted a NDA for Silenor for the treatment of insomnia.  The active ingredient is doxepin, which has been available for years.The effect of the drug can be expected to be very modest, side effects unfavorable when compared to Ambien or Lunesta, and with both significant...
January 25, 2008
Artificial Cervical Disc Looks Promising
Analysis of: Artificial Disc Versus Fusion: A Prospective, Randomized Study With 2-Year Follow-up on 99 Patients | www.medscape.com
Author: GLG Expert Contributor
Outcomes in patients implanted with the artificial disc compare favorably with single level ACDF after 2 years.
Daniel WynnJanuary 18, 2008
Major Win For Glaxo with Xenoport for Restless Legs syndrome -- Next Blockbuster?
Analysis of: GlaxoSmithKline and XenoPort report positive top-line results of second phase 3 restless legs syndrome trial for XP13512/GSK1838262 | www.pipelinereview.com
Author: Daniel Wynn, Director, Clinical Research, Consultants In Neurology Ltd.
Xenoport's trial for XP13512 in restless legs syndrome (RLS) shows strongly positive 9 month data in second phase 3  trial, should be a major win in the marketplace.  RLS represent a major unmet need, for drugs with sustained efficacy and high tolerability.
November 30, 2007
Lacosamide Should Solidify UCB as CNS Drug Leader
Analysis of: UCB Announces FDA Filing for lacosamide in the Treatment of Partial Onset Seizures | www.reuters.com
Author: GLG Expert Contributor
UCB has filed new drug application for regulatory approval for lacosamide through FDA and European Medicines Agency.  Primary indication would be the treatment of partial onset seizures (epilepsy)
November 26, 2007
Taisho/Pfizer’s TS-032 for Schizophrenia: A New Player in mGluR Field
Analysis of: Taisho and Pfizer Sign a Letter of Intent for Taisho's Schizophrenia Drug Candidate | biz.yahoo.com
Author: GLG Expert Contributor
Pfizer has tentatively agreed to partner with Taisho to develop and commercialize the new schizophrenia drug TS-032 outside Japan.  This move may support Pfizer’s efforts to expand its share in the antipsychotic market beyond Geodon.
November 21, 2007
AstraZeneca’s Seroquel XR: Acute….Maintenance…What’s next?!
Analysis of: Seroquel XR Receives Approval From FDA for Maintenance Treatment of Schizophrenia | pharmalive.com
Author: GLG Expert Contributor
FDA has recently approved once-daily Seroquel XR for maintenance treatment of adult schizophrenia patients.  Risk of relapse and recurrence of acute psychotic symptoms were 84% less in patients receiving Seroquel XR vs. placebo.

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