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GLG News by Hematologists who Treat Thrombocytopenias in the U.S.

Analysis of: Randomized Phase II Study of Vandetanib Alone or With Paclitaxel and Carboplatin as First-Line Treatment for Advanced Non–Small-Cell Lung Cancer (jco.ascopubs.org)
A VEGF inhibitor that appears to work well with chemo in non small cell lung carcinoma.
Analysis of: Merck KGaA: Overall Survival in First-Line NSCLC Reaches 15 Months (www.drugs.com)
"New data from pivotal FLEX study reveal that patients treated with Erbitux who develop early skin rash show median overall survival of 15 months (p<0.001)" This is the trial that showed Erbitux + chemo prolonged survival minimally when compared to chemo alone. Now we know the ones who develop a...
Analysis of: Roche Says Tarceva Data Promising (online.wsj.com)
Tarceva can maintain a remission in non small cell lung cancer after initial therapy with other agents. Just like Lilly's Alimta
Analysis of: Phase III Trial of Consolidation Therapy With Yttrium-90–Ibritumomab Tiuxetan Compared With No Additional Therapy After First Remission in Advanced Follicular Lymphoma (jco.ascopubs.org)
Addition of Zevalin after a CR or PR in low grade, follicular lymphomas adds to CR rates and improves time to progression. The implication is that this will result in improved survivals.
Analysis of: Pharma need not worry too much about President Obama (www.pharmatimes.com)
The implication is that our new chief executive has "bigger fish to fry" than attaching drug costs??
Analysis of: Glaxo Plans 12% Reduction in Its U.S. Drug Sales Force (online.wsj.com)
"As part of the restructuring, the company plans to group its sales staff around specific treatment areas" including oncology, probably
Analysis of: Genentech Submits Application to U.S. Food and Drug Administration for Avastin in the Most Aggressive Form of Brain Cancer (www.gene.com)
Genetech is seeking FDA approval for use in the most malignant of brain tumors, Glioblastomas.
Analysis of: Targeting EGFR in Colorectal Cancer (content.nejm.org)
Measuring mutated K-RAS will show who will NOT respond to ImClone's Erbitux or Amgen's Vectibix. Thus to use either in CRC will not be particularly effective.
Analysis of: Panel Calls for Vaccine for Adult Smokers (online.wsj.com)
31 million more doses of Pneumovax yearly in the US??
Analysis of: Cell Genesys Announces Termination of VITAL-1 Phase 3 Trial of GVAX Immunotherapy for Prostate Cancer (pharmalive.com)
Cell Genesys is basically stopping work on GVAX inview of failure in two trials. The cause of the failure is not readily apparent.

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