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GLG News by Hematologists who Treat Myelodysplastic Syndromes

Analysis of: Baxter Rival APP Steps In Quickly To Supply Heparin (online.wsj.com)
APP wants to jump into the void created by Baxter's "allergic" problems related to Chinese suppliers. BUT APP appears to also obtain some of it's product from China and with FDA's scrutiny I would not bet on continued supplies.
Analysis of: Kidney Cancer Drug Linked to Higher Rate of Heart Problems (www.washingtonpost.com)
Sutent is associated with cardiac dysfunction!?
Analysis of: F.D.A. Seeks to Broaden Range of Use for Drugs (www.nytimes.com)
As an oncologist we are aware of a drugs efficacy in conditions other than what it has been approved. Avastin in breast cancer; Nexavar and Erbitux in lung cancer, Taxotere in sarcomas. This list would be voluminous and would be a real benefit for patients BUT.......
Analysis of: Æterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers (www.pipelinereview.com)
Targeting gynecologic tumors with a "hormone" attached to an effective chemotherapeutic agent.
Analysis of: B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis (content.nejm.org)
Very preliminary but if a larger study is confirmatory, and even before in the community, this agent will be used in MS.
Analysis of: In Second Trial, Avastin Is Found Effective in Treating Breast Cancer (www.nytimes.com)
"Genentech said Tuesday that a new clinical trial had shown that its best-selling drug Avastin was effective in treating breast cancer, a finding that could increase the chances that the product will be approved for that use."
Analysis of: Problems in Blood Drug Lead to Halt by Factory (www.nytimes.com)
If there is a production delay in "standard" heparin, it will open the door for LMWH preparations. Which ones? Sanofi-Aventis's Lovenox
Analysis of: Single autologous stem-cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized clinical trial (bloodjournal.hematologylibrary.org)
Thalidomide post single stem cell transplant is as good as two transplants back to back (tandem.)
Analysis of: Epistem plc and AstraZeneca Complete Plucked Hair Biomarker Study for Oncology Drug Development (www.foxbusiness.com)
Analysis of RNA obtained from hair follicles can be used to guide drug development and therapy
Analysis of: Diabetes Study Partially Halted After Deaths (www.nytimes.com)
".... a major federal study of more than 10,000 middle-aged and older people with Type 2 diabetes (DM) has found that lowering blood sugar actually increased their risk of death, researchers reported Wednesday."

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