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GLG News by Hematologists who Treat Myelodysplastic Syndromes

Analysis of: FDA Adds More Black-Box Warnings To Anemia Drugs From Amgen, J&J (online.wsj.com)
The FDA is now warning of increased death & tumor growth in breast and cervical cancer patients.
Analysis of: The High Cost of a Cancer Drug (www.nytimes.com)
This editorial is questioning the use of this expensive agent in patients with metastatic breast cancer when it only increases time to progression 5.5 months.
Analysis of: Two Tests Added to Recommended List to Prevent or Detect Colorectal Cancer (www.nytimes.com)
Virtual Colonoscopy and stool analysis for DNA alterations for colon cancer, are being recommended for screening.
Analysis of: Acute Pulmonary Embolism (content.nejm.org)
     With recent developments in preparation of unfractionated heparins (http://www.nytimes.com/2008/03/06/health/06heparin.html?_r=1&ref=health&oref=slogin) not only are the LMWH varieties more effective as well as cheaper when all of the co factors are included, they...
Analysis of: Drug Pitchmen: Actor, Doctor or Pfizer’s Option (www.nytimes.com)
"Celebrity" advertisements of percription drugs are disingenuous?
Analysis of: Teva Announces Approval Of Generic Camptosar(R) (www.pipelinereview.com)
Camptosar is being made in Israel I would imagine, and the price differential compared to Pfizer's brand name drug is????
Analysis of: Aetna to Delay Reduced Colonoscopy Coverage (online.wsj.com)
The original plan was to not provide for anesthesia support during the uncomfortable, to say the least, colonoscopys as well as upper endoscopy.
Analysis of: Novartis Late-State Cancer Trial Is Stopped Early After Meeting Goal (online.wsj.com)
It shares a common mechanism of action with Wyeth's Torisel (mTOR inhibition) and will at least share the market for recurrence after a TK inhibitor fails.
Analysis of: Higher Risks Found for Anemia Drugs (online.wsj.com)
Meta analysis of multiple papers shows an increased risk of dealth in cancer patients receiving Epo products.
Analysis of: CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib (bloodjournal.hematologylibrary.org)
IF this agent works it is ORAL and will certainly be more acceptable to patients than the IV Velcade.

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