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GLG News by Hematologists and Oncologists in Private Practice (US)

Analysis of: Bad Cancer Tests Drawing Scrutiny (online.wsj.com)
Oncologists rely heavily on hormone and HER-2 status to guide treatment recommendations for women with breast cancer.  If the results of these important tests are incorrect up to 20% of the time, we may be suboptimally treating many breast cancer patients.
Analysis of: Randomized Phase II Study of Gemcitabine Plus Cisplatin, With or Without Cetuximab, As First-Line Therapy for Patients With Advanced or Metastatic Non–Small-Cell Lung Cancer (jco.ascopubs.org)
Medical oncologists have "maxed out" on  chemo combinations in lung cancer.  It is clear that biologic agents need to be incorporated into our treatment regimens in order to move forward. Erbitux is safer and can be used in a broader population of lung cancer patients than Avastin.
Taral Patel, MD, Oncologist
Taral Patel, MD, Oncologist
Mid Ohio Oncology Hematology Inc.
December 7, 2007
Avastin in breast cancer
Analysis of: F.D.A. Criticizes Avastin Use for Breast Cancer (www.nytimes.com)
“On face value the data look very good,” said Buzdar, who voted with the slim (5-4) majority against the drug. In the study that was the basis of Genentech’s application, Avastin appeared to slow the progress of the disease. advanced breast cancer who had already tried other drugs. He said he’s never...
Brian Abbott, MD, Medical Director of Hematology
Brian Abbott, MD, Medical Director of Hematology
Big Sky Oncology
Analysis of: Vidaza vs Dacgoen for MDS (www.newratings.com)
There is no reason to believe Dacogen is inferior to Vidaza. In some studies, Dacogen seems to produce a deeper quality of response, and may also prove more beneficial in AML.
Brian Abbott, MD, Medical Director of Hematology
Brian Abbott, MD, Medical Director of Hematology
Big Sky Oncology
Analysis of: Phase II study of lenalidomide in transfusion-dependent, low- and intermediate-1-risk myelodysplastic syndromes with karyotypes other than deletion 5q (bloodjournal.hematologylibrary.org)
Revlimid benefits are often over-stated in non-5Q minus MDS. The cost is a hurdle for many patients with poor prescription plans. Vidaza and Dacogen seem superior in my experience for higher risk patients.
November 6, 2007
Too little, too late
Analysis of: ADVENTRX Provides Update on Cofactor(R) Program (www.pipelinereview.com)
CoFactor would have been a great drug 15 years ago.
Analysis of: Varian's New Rapid Arc Delivery (www.varian.com)
This article reports on Varian's answer to Tomotherapy which has been gaining some market share in the Radiation Oncology linear accelerator arena. Tomotherapy has a good product but requires a shift in treatment planning technique and complete replacement of hardware. There have been reports about...
Analysis of: More Prominence Urged for Heart Risks in Breast Cancer Treatment (www.medpagetoday.com)
The current understanding of heart risks from chemotherapy does not stop oncologists from giving chemotherapy for early breast cancer in those who need it. Better drugs for preventing relapse are certainly welcome, when they are developed.
Analysis of: Curis, Inc. Announces Initiation of Expansion Cohort in Collaborator Genentech's Phase I Clinical Trial of a Systemically Administered Hedgehog Antagonist (www.pipelinereview.com)
What are my thoughts?  Not much. This drug has just entered early phase studies and the most that we can make of it is that people can tolerate it.
Analysis of: US FDA approves Bristol-Myers breast cancer drug (www.reuters.com)
Ixempra is a new drug with big implications.

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