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GLG News by Hematologists (US)

April 9, 2008
Bexarotene (Ligand) It's SPIRIT is alive in a subset of lung cancer patients.
By a GLG Expert Contributor
Analysis of: Phase III Trial Comparing Carboplatin, Paclitaxel, and Bexarotene With Carboplatin and Paclitaxel in Chemotherapy-Naïve Patients With Advanced or Metastatic Non–Small-Cell Lung Cancer: SPIRIT II (jco.ascopubs.org)
This study, as well as a companion paper in the same JCO (Spirit I & II) http://jco.ascopubs.org/cgi/content/full/26/11/1886 Show that the subset of patients with markedly increase in lipids, survived > 12 mo!!
April 9, 2008
Oncophage(R) : Let's wait until the results are duplicated in Costa Rica.......
By a GLG Expert Contributor
Analysis of: Oncophage(R) Approved in Russia for the Treatment of Intermediate-Risk Kidney Cancer (www.pipelinereview.com)
Antigenics Inc. (NASDAQ: AGEN) had to go to Russia to perform this clinical trial???
April 4, 2008
Genetic drivers of lung cancer risk identified.
By a GLG Expert Contributor
Analysis of: Studies Find Genetic Link to Smoking (www.nytimes.com)
Gene driven nicotine receptors will predispose to increased smoking. What will this lead to?? Increased addiction due to mutations increases cancer risk.
April 2, 2008
An unmet need still unmet, tough luck for Pfizer
By a GLG Expert Contributor
Analysis of: Pfizer Ends Clinical Trial Of Melanoma Treatment (online.wsj.com)
Drug (monoclonal ab?) failed in a phase III trial vs chemotherapy (not particularly effective.)
April 1, 2008
Amgen, Well at least they have Aranesp. (Whoops!)
By a GLG Expert Contributor
Analysis of: Unexpected Toxicity with Panitumumab Plus Chemotherapy-Bevacizumab Combo in Colorectal Cancer (www.oncology-times.com)
Vectibix's undue toxicity without obvious benefits punctures Amgen's hope of finding a first or even second line use for this EGFR directed monoclonal antibody.
April 1, 2008
Implications of mechanism's of action? Who cares if it works!
By a GLG Expert Contributor
Analysis of: OXiGENE Begins Phase II NSCLC Trial of ZYBRESTAT(TM) in Combination with Bevacizumab and Chemotherapy (www.pipelinereview.com)
OXiGENE, Inc's., ZYBRESTAT(TM) (fosbretabulin), a vascular disrupting agent (?) is being given with Taxol/Carboplatin (T/C) in a randomized Phase II study. Soooo T/C with or without ZYBRESTAT.
March 31, 2008
Well at least they have Procrit (Whoops!)
By a GLG Expert Contributor
Analysis of: Cancer risk seen with J&J foot gel: FDA (uk.reuters.com)
 "A Johnson & Johnson foot gel used by diabetics may increase the risk of cancer and death, U.S. health officials said on Thursday in announcing an investigation into the issue."
March 31, 2008
New Therapy for Hormone Refractory Prostate CA. Maybe!!!
By a GLG Expert Contributor
Analysis of: Oxford BioMedica Report Encouraging New Phase II Trial Results With TroVax(R) in Prostate Cancer (www.pipelinereview.com)
Phase II results ++
March 28, 2008
Can I eat until my IQ drops to 120.......?
By a GLG Expert Contributor
Analysis of: Study Ties Belly Fat to Dementia (online.wsj.com)
"Belly Fat" in middle age can be associated with the development of dementia as one ages.
March 27, 2008
CT scanning to detect early lung cancers? Flawed due to ethical concerns
By a GLG Expert Contributor
Analysis of: Cigarette Company Paid for Lung Cancer Study (www.nytimes.com)
Support from a cigarette manufacturer raises questions as to the conclusions from this study which says early detection by repetitive CT's can improve cancer cure rates by early detection. (making smoking safer?)

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