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GLG News by Hematologist who treat patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

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October 24, 2008
A target may well decrease the market for EGFR inhibitors (Erbitux & Vectibix) in colon cancer (CRC)
Analysis of: Targeting EGFR in Colorectal Cancer | content.nejm.org
Author: GLG Expert Contributor
Measuring mutated K-RAS will show who will NOT respond to ImClone's Erbitux or Amgen's Vectibix. Thus to use either in CRC will not be particularly effective.
Donald FlemingOctober 24, 2008
The vaccine approach to cancer has yet to succeed
Analysis of: Cell Genesys Announces Termination of VITAL-1 Phase 3 Trial of GVAX Immunotherapy for Prostate Cancer | pharmalive.com
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
Be cautious of vaccine approaches to cancer No cancer has had success with the use of vaccine therapy We are far from figuring out the reason for failure of vaccines to treat cancer
October 23, 2008
Vaccinate smokers?? what is the agenda and the employer of "The Advisory Committee on Immunization Practices."
Analysis of: Panel Calls for Vaccine for Adult Smokers | online.wsj.com
Author: GLG Expert Contributor
31 million more doses of Pneumovax yearly in the US??
October 21, 2008
GVAX: Why did it fail? Let me list the possible ways......
Analysis of: Cell Genesys Announces Termination of VITAL-1 Phase 3 Trial of GVAX Immunotherapy for Prostate Cancer | pharmalive.com
Author: GLG Expert Contributor
Cell Genesys is basically stopping work on GVAX inview of failure in two trials. The cause of the failure is not readily apparent.
Donald FlemingOctober 20, 2008
We must hit the cancer target by genetics or whatever technique
Analysis of: Genetic Research May Help Pick Patients' Best Cancer Drugs | online.wsj.com
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
Targeted therapy for cancer is the new trend Targeted therapy will allow the use of more expensive drugs to be more practical We need to focus on hitting a target more than ever
Donald FlemingOctober 20, 2008
Government Run Cancer care
Analysis of: Roche Cuts Price of Cancer Drug | online.wsj.com
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
There has been distubing trends in nationalized health care in regrds to cancer care Recently the UK made an absolutely shocking decision on renal cancer therapy, as it has in other cancers in the past Hopefully through advances in predicting cancer therapy outcomes via microarray etc. we can...
October 15, 2008
Thyroid cancer: When it rains it pours
Analysis of: Phase II Trial of Sorafenib in Advanced Thyroid Cancer | jco.ascopubs.org
Author: GLG Expert Contributor
 as per an accompanying editorial "In conclusion, it is particularly gratifying that years of research in tumor biology and drug development have coalesced. Translation of these research advances into therapeutic benefits for patients with refractory thyroid cancer, and a related paradigm shift...
October 15, 2008
Genetically determined cancer therapy: It will be a wash.
Analysis of: Genetic Research May Help Pick Patients' Best Cancer Drugs | online.wsj.com
Author: GLG Expert Contributor
Genetic determinants will decrease use of some drugs due to mutations such as Kras which indicate less chance of response and thus the chemo agents will not be used.
Donald FlemingOctober 9, 2008
Beta trial negative, but is it truely blinded
Analysis of: Genentech Set Back by Cancer-Drug Study | online.wsj.com
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
Beta trial implies that Avastin adds to the effectiveness of the other Genentech drug, Tarceva There is an attempt to change treatment gudelines in second line non small treatment
October 8, 2008
Avastin/Tarceva/Roche/OSI/Genentech: So much for "synergy" in lung cancer
Analysis of: Genentech Set Back by Cancer-Drug Study | online.wsj.com
Author: GLG Expert Contributor
The primary goal was improved survival- NOT REACHED!!

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