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GLG News by Hematologist who treat patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Analysis of: Cigarette Company Paid for Lung Cancer Study (www.nytimes.com)
Support from a cigarette manufacturer raises questions as to the conclusions from this study which says early detection by repetitive CT's can improve cancer cure rates by early detection. (making smoking safer?)
Analysis of: Prostate-Cancer Treatment Questioned (online.wsj.com)
Hormone blocking therapy is added to radiation, unnecessarily, in early prostate cancer patients. The result in early stage patients is unnecessary side effects and reduced quality of life. Go figure.
Analysis of: Researchers Find Cause of Severe Allergic Reaction to Cancer Drug (pharmalive.com)
Antibodies have been identified that explain allergic reactions that can terminate it's use in individuals who "react."
Analysis of: Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab (content.nejm.org)
This exceedingly rare condition produces organ damage due to infiltration of blood eosinophils. Steroids are the only effective therapy in the non myeloproliferative subset of patients, so for the chosen few this drug will be invaluable.
Analysis of: Phase II Randomized Controlled Trial of an Epidermal Growth Factor Vaccine in Advanced Non–Small-Cell Lung Cancer (jco.ascopubs.org)
Vaccination with EGF was used in a maintenance situation after initial chemo. No only did it produce EGF antibodies BUT the antibody response was correlated with survival!!
Analysis of: Lenalidomide for the Treatment of B-Cell Malignancies (jco.ascopubs.org)
Revlimid has significant activity in non Hodgkin's lymphomas (NHL)as well as chronic lymphatic leukemia (CLL) although why is somewhat unclear.
Analysis of: Doctors See How Cancer Drug Can Damage Kidneys (www.washingtonpost.com)
Avastin, an antiangiogenic agent used in cancer and other disorders, may have more side effects than originally recognized including proteinuria as well as kidney damage.
Analysis of: Cutting Dosage of Costly Drug Spurs a Debate (www.nytimes.com)
Pharma recommends more drug than may actually be needed. This does not apply just to Cerezyme, but the Epo products (Amgen & J&J), Avastin (Genentech.)
Analysis of: 5 Guilty of Fraud in Health Care Finance (www.nytimes.com)
Prison terms to be handed out for fraud by a health care financing firm. Go figure?
Analysis of: Platelet Treatment Wins FDA Panel's Support (online.wsj.com)
This is an agent, approved for use with restrictions, in ITP.

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