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GLG News by Hematologist who treat patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

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August 29, 2008
Bcl-2 apoptosis inhibition: The next "best" thing?
Analysis of: Expanding Circle of Inhibition: Small-Molecule Inhibitors of Bcl-2 as Anticancer Cell and Antiangiogenic Agents | jco.ascopubs.org
Author: GLG Expert Contributor
Bcl-2 inhibition by small molecules stands to be the next avenue for antineoplastic therapy- Looks like the real deal!
August 29, 2008
So Much for GVAX.... for now?
Analysis of: Cell Genesys Ends Clinical Trials For Prostate Cancer Treatment | online.wsj.com
Author: GLG Expert Contributor
No reason for the increased mortality vs Chemo alone was identified. Cell Genesys is looking into where to go now.
August 29, 2008
Velcade in myeloma 1st line. Am I s?urprised
Analysis of: Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma | content.nejm.org
Author: GLG Expert Contributor
Velcade + classic Melphalan/ Prednisone  (MP) is better than MP alone. No surprise
August 25, 2008
Amgen's long awaited product to treat chronic ITP will be well receive.
Analysis of: Amgen Blood-Disorder Drug Gains Clearance | online.wsj.com
Author: GLG Expert Contributor
Chronic ITP is not all that uncommon and becomes a quality of life issue with chronic steroid use as well as agents that are normaly used in neoplasia and even derivatives of male hormones.
August 21, 2008
Artificial red blood cells (RBC'S): preliminary but very promising.
Analysis of: Scientists Find Way to Create Red Blood Cells | online.wsj.com
Author: GLG Expert Contributor
Advanced Cell Technology in Worcester, Mass., the University of Illinois at Chicago and the Mayo Clinic in Rochester, Minn. scientists say they've found an efficient way to make red blood cells from human embryonic stem cells. Impreesive!
August 21, 2008
Cervical Cancer Vaccines: Hope or Hype?
Analysis of: Drug Makers’ Push Leads to Cancer Vaccines’ Fast Rise | www.nytimes.com
Author: GLG Expert Contributor
Cervical cancer vaccines manufactured by Merck and Glaxo have been hyped, pushed and if the companies have their way, mandated by various states and organizations. (Who is benefiting? Patients or the politicians?) There are many unanswered questions but marketing and mandates press on!
August 20, 2008
Sunitinib vs Interferon: No contest at the onset
Analysis of: Economic Evaluation of Sunitinib Malate for the First-Line Treatment of Metastatic Renal Cell Carcinoma | jco.ascopubs.org
Author: GLG Expert Contributor
When using a model (of whose desin?) Pfizer's Sunitinib (Sutent) was found to be cost effective by Pfizer people? Surprise!!!
August 19, 2008
Cole & Pfizer: Happy together in NSCLCA (non small cell lung cancer)
Analysis of: Randomized Phase II Trial of a Toll-Like Receptor 9 Agonist Oligodeoxynucleotide, PF-3512676, in Combination With First-Line Taxane Plus Platinum Chemotherapy for Advanced-Stage Non–Small-Cell Lung Cancer | jco.ascopubs.org
Author: GLG Expert Contributor
"The investigator-assessed objective response rate (complete and partial response), including both confirmed and unconfirmed responses, was 38% in the PF-3512676 plus chemotherapy arm and 19% in the chemotherapy-alone arm (P = .043)." In other words. IT MAY WORK!
Donald FlemingAugust 14, 2008
UK the model for US healthcare?
Analysis of: UK Says Kidney Cancer Drugs Are Too Pricey | www.pharmalot.com
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
In this election year some have encouraged adoption of socialized medical services UK healthcare is an example of what some in this country have said we need to model our future healthcare system The recent use of biologics such as the TKIs have resulted in options for...
August 13, 2008
Hepcidine quantification is a valuable tool for iron balance analysis
Analysis of: UCLA And Biotech Company Develop First Blood Test To Measure Key Hormone That Regulates Iron | www.medicalnewstoday.com
Author: GLG Expert Contributor
Hepcidine is a key regulator of iron balence. Despite the availability of some iron makers (ferritin, sideremia and transferrin), hepcidine dosage can aid in the interpretation of complex clinical cases. However, its use could be limited to very particular clinical cases.

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