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GLG News by Heart Failure Specialists (US)

Analysis of: Pfizer Abandons Exubera, Posts 77% Earnings Decline (online.wsj.com)
Ask any patient with diabetes what they want for a therapeutic option and they'll tell you non-injectable insulin.  They understand that all the other medications are a poor substitution for the replacement of pancreatic insulin and they are tired of taking multiple pills each day. So why did...
Analysis of: Enrollment Reaches 110 Patients In Investigator Initiated, Randomized Trial Of OrbusNeich's Genous(TM) Bio-Engineered R Stent(TM) (www.medicalnewstoday.com)
The failure of drug eluting stents in the eyes of the public and in the medical community is probably not a failure of the device as much as a failure of patient managment.  It is clear that atherothrombotic vascular disease requires a life-long commitment to blood pressure, cholesterol, and blood...
Daniel Weiss, MD, Chief Medical Officer
Daniel Weiss, MD, Chief Medical Officer
Vicor Technologies, Inc.
Analysis of: Medtronic Pulls Heart Device Wires (www.thestreet.com)
The current recall is yet another in the world of cardiac rhythm devices. The ICD market is already shakey and may be adversely affected. Will Medtronic's reputation suffer?
Analysis of: Medtronic Voluntarily Suspends Distribution Of Sprint Fidelis® Defibrillation Leads (www.medicalnewstoday.com)
1) Data only shows trend towards higher lead fracture, not statistically significant on current numbers. 2) Medtronics did the "right thing". No attempts to hide data. 3) Number of potential claims should be minimal, as this is NOT a recall. Rather, more carefull monitoring of the already implanted...
Analysis of: Patients Warned as Maker Halts Sale of Heart Implant Part (www.nytimes.com)
With the industry still struggling to recover from the relatively recent Guidant ICD recalls it is possible that this latest ICD lead recall will affect overall ICD implant rates.  It is also possible that Medtronic, the leader in the ICD market, will suffer a loss of market share due to this latest...
Analysis of: Isis Reports Positive Results of Phase 2 Study of ISIS 301012 in Heterozygous FH Patients (www.pipelinereview.com)
This is a well written article of an impressive study. Despite small sample size, there was a clear dose response that achieved statistical significance witha  VERY robust LDL reduction in paitents already on maximal conventional lipid lowering agents. This paves the way to larger and longer term...
Analysis of: Isis Reports That ISIS 301012 is Well Tolerated in Patients Treated for Five Or More Months (www.pipelinereview.com)
ISIS 301012 is an important agent in the armenentarium to treat an unmet group of patients with refractory hypercholesterolemia or familial hypercholesterolemia. With outcome directly proportional to amount of LDL lowered, it is important to not just control LDL, but also lower it to aceptable...
October 10, 2007
Great potential
Analysis of: Isis Reports That ISIS 301012 is Well Tolerated in Patients Treated for Five Or More Months (www.pipelinereview.com)
I think this drug has great potential for refractory high LDL and possibly in Acute Coronary Syndrome and CAD patients.
Analysis of: Aastrom Announces Positive Interim Results From Phase I/II Study Involving Use of Vascular Repair Cells in Patients With Critical Limb Ischemia (www.pipelinereview.com)
There will be an increased impetus to start clinical trials with stem cells in peripheral vascular disease in order to avoid amputations (the same is true for osteonecrosis of the hip). As the prevalence of diabetes increases in the Western world, the demand for this type of therapies will be increasing....
Analysis of: Microsoft launches Web site to hold medical records (uk.reuters.com)
Medical practice is behind financial serivces in terms of computerization of records. There is no one medical record system(like Microsoft Word) that is used by many practioners.  Inaccessiblity of old medical records leads to increased cost of care because of unnecessary repetition of medical...

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