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GLG News by General Internal Medicine Physicians (US)

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November 24, 2008
Glossing over the increased cervical cancer occurences
Analysis of: Gardasil, Merck's Cervical Cancer Vaccine, Demonstrated Efficacy in Preventing HPV-Related Disease in Males in Phase III Study | www.fiercebiotech.com
Author: GLG Expert Contributor
The safety data showing statistically significant increased rates of cervical cancer in women vaccinated against HPV was buried.  Although presented at the FDA hearing, the data did not make it into the package insert for the biological. Briefly, the data showed that women who had evidence of...
August 27, 2008
A rough in the diamond
Analysis of: FDA Alert: Hemorrhagic or Necrotizing Pancreatitis in Patients Taking Byetta | www.fda.gov
Author: GLG Expert Contributor
If truly an association, this will alter the use of this drug.
August 8, 2008
This makes a lot of cents...
Analysis of: Blood pressure drugs may protect against Alzheimer's | www.washingtonpost.com
Author: GLG Expert Contributor
I think that we primary care doctors have known all along that controlling several risk factors that we commonly see not only makes people live longer, but also more "intact" as they age.  I can look back over the last 28 years of practice and see that those patients who went downhill faster were...
July 28, 2008
Onglyza - ? engagement ring for Astra Zeneca and Bristol-Myers Squibb
Analysis of: AstraZeneca and Bristol-Myers Squibb Submit New Drug Application in the United States and Marketing Authorisation Application in Europe for ONGLYZA™ (Saxagliptin) for the Treatment of Type 2 Diabetes | www.astrazeneca.com
Author: GLG Expert Contributor
DDP4 inhibitor class fairly new.  Another arrow in the theraputic quiver
July 18, 2008
Fractures from Fosamax???
Analysis of: Drugs to Build Bones May Weaken Them | www.nytimes.com
Author: GLG Expert Contributor
Patients may ask about this.  Haven't heard anyone yet.
June 23, 2008
I agree that EMRs are not ready for most of us primary care doctors...
Analysis of: Most Doctors Aren’t Using Electronic Health Records | www.nytimes.com
Author: GLG Expert Contributor
EMRs are quite expensive, possibly one of the bigger outlays of cash I can think of.  EMRs are also a work in evolution, much like operating software:  who wants to invest a lot of money on Vista when rumors of a new and better program are out there?  The enormous stress of putting one...
June 6, 2008
Symbicort will give a lift to the little ones
Analysis of: AstraZeneca Submits an sNDA for SYMBICORT(R) for the Treatment of Asthma in Children as Young as Age Six | www.pipelinereview.com
Author: GLG Expert Contributor
Good drug with rapid onset.  ? if will create some confusion with adult dosing    
May 29, 2008
I find it hard to believe...
Analysis of: New data show Tekturna HCT® is twice as effective at reducing blood pressure than the diuretic HCT alone | www.novartis.com
Author: GLG Expert Contributor
I have used this medication a few times and, although good, it is not a powerhouse like some others. It looks to me as if the claim of "double" the potency with HCTZ is more smoke and mirrors.              
May 27, 2008
Aliskiren the good, bad and the quest.
Analysis of: New data show Tekturna HCT® is twice as effective at reducing blood pressure than the diuretic HCT alone | www.novartis.com
Author: GLG Expert Contributor
I think the long affect of Aliskiren (3-4 days ) after the last pill is both a benefit and a risk; it is good in the setting on noncompliance but quite a challenge  when  trying to reverse  the hypotensive effects in  emergency situation. It is interesting that it is more effective...
April 4, 2008
Another reason to use Lipitor
Analysis of: Lipitor Provided an Unexpectedly Potent Heart Benefit in Patients with Chronic Stable Angina, According to New Study | www.pipelinereview.com
Author: GLG Expert Contributor
Lipitor is the only statin tested to reduce ischemic stroke. The new study also proved its role in reduce angina and MI

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