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GLG News by General Internal Medicine Physicians (Europe)

Analysis of: CRESTOR Demonstrates Dramatic CV Risk Reduction in a Large Statin Outcomes Study (www.astrazeneca.com)
Jupiter study demonstrated significant reduction of cardiovascular morbidity and mortality in patients with high hs-CRP and acceptable lipid profile. This study demonstrates that rosuvastatin might play a major role in modulating inflammation pathways predisposing to cardiovascular diseases....
Analysis of: Sirtris Pharmaceuticals Presents Results of Studies of SIRT1 Activators at 6th Annual Metabolic Diseases Drug Discovery and Development World Summit (www.pipelinereview.com)
SIRTRIS is one of the leading "sites" worldwide on this field. They have profound knowledge about the human sirtuin gene family.
Analysis of: Alteon Initiates Phase 2 Trial of ALT-2074 in Diabetes and Haptoglobin 2-2 (www.pipelinereview.com)
The article is important because it informs about the start of a phase-2 clinical trial in diabetics with CVD which uses a therapeutic principle, which is distinct from the standard diabets type two drugs, i. e. the compound ALT-2074 addresses free radical formation. Moreover, the trial is "genotype-guided"....
Analysis of: Updated Position Statement for Calcium Intake in Postmenopausal Women (www.medscape.com)
Calcium must always be seen in conjunction with an individiual's vitamin D -and magnesium status.
Analysis of: Merck's Investigational MK-0524 Significantly Reduced Flushing Caused By Extended-Release Niacin in Phase II Study (biz.yahoo.com)
"There was no difference in lipid response when MK-0524 with ERN was compared to treatment with ERN alone." However.......
Analysis of: Chocoholics rejoice! More benefits found in heart study (www.cnn.com)
The available data about the effects of dark chocolate, or cacao flavanols, per se, on the cardiovascular system are indeed looking very promising. But it should be dark chocolate, containing more than 70 % cacao.
Analysis of: No Scientific Evidence Supporting Effectiveness or Safety of Compounded Bioidentical Hormone Therapy (www.acog.org)
Important is not the right word for the ACOG article in question. More important is a sound and solid scientific debate about the issue.

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