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GLG News by Emergency Medicine Physicians (Asia)

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October 1, 2007
Fentanyl: Neglect on the likelihood of a perturbed metabolism
Analysis of: FDA Warns About Misuse Of Fentora Cancer Pain Drug | www.medicalnewstoday.com
Author: GLG Expert Contributor
There were certain unresolved issues before the clinical usage of fentanyl in cancer patients. There are interesting metabolic features of this potent drug. First of all, its LD50 (the dosage causing the %50 death to applied laboratory animals) value is 100 times lower in primates than rodents (mice,...
October 1, 2007
Differentiation Agents for Solid Cancers: The Time Has Came
Analysis of: Novacea Initiates Phase 2 Trial of Asentar in Advanced Pancreatic Cancer | www.pipelinereview.com
Author: GLG Expert Contributor
Differentiation-inducing liposoluble vitamins are being used for about 20 years in hematological oncology, after the finding that all-trans-retinoic acid (ATRA) differentiates promyelocytic leukemia clones leading clinical benefits. With this discovery, interest into retinoids (Vitamin A derivatives)...

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