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GLG News by Coagulation Factor VIII Prescribers

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June 2, 2008
Lenalidomide is on a surge
Analysis of: Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia | bloodjournal.hematologylibrary.org
Author: GLG Expert Contributor
Lenalidomide is recently proving that its potential is not limited to myeloma, but can be used also in other B-cell malignancy settings such as lymphoma and CLL. CLL, in particular, needs light and yet efficacious treatments, particularly in the setting of pretreated (at times heavily) patients.
April 2, 2008
Hype and hope for another cancer vaccine
Analysis of: Oxford BioMedica Report Encouraging New Phase II Trial Results With TroVax(R) in Prostate Cancer | www.pipelinereview.com
Author: GLG Expert Contributor
Biological efficacy has been shown for a number of cancer vaccines. Clinical efficacy has been shown in few of them. Clinical benefit just in one: idiotype vaccine for B-cell lymphoma. TroVax still has to clear the last hurdle, and likely also the second one.
January 25, 2008
Preventing Bariatric Surgery Deaths
Analysis of: Pinning Down Mortality Rates After Bariatric Surgery | www.medscape.com
Author: Forrest Rubenstein, Cardiac, Thoracic and Vascular Surgeon, Rubenstein Cardiovascular and Thoracic Surgery
 Bariatric surgery is a major operative procedure that caries significant morbidity and mortality risks due to the comorbid diseases seen in this patient population.  This procedure is increasing in frequency as more patients are willing to have it and more surgeons are becoming proficient. The...
January 9, 2008
Another player in MM treatment?
Analysis of: Kosan Opens TIME-1 Pivotal Phase 3 Trial in Multiple Myeloma | www.pipelinereview.com
Author: GLG Expert Contributor
Several novel compounds have recently changed the way myeloma is treated, but there is still plenty of room for improvement in myeloma treatment. This trial cold not just prove that tanespimycin works, but that also synergizes with a fashionable and efficacious agent like bortezomib&nb...
November 30, 2007
Orphan status does not mean efficacy
Analysis of: Vaxon Biotech Obtains Orphan Status for Lung Cancer Vaccine | www.therapeuticsdaily.com
Author: GLG Expert Contributor
Orphan status is a good thing to foster development of a compound/formulation Orphan status by no means allow to predict clinical efficacy or clinical benefit
October 29, 2007
The approval of topotecan
Analysis of: GSK receives approval for Hycamtin(R) (topotecan) capsules for the treatment of relapsed small cell lung cancer | www.pipelinereview.com
Author: GLG Expert Contributor
Very good market prospective for topotecan, given that these patients have very little if anything at all to be offered after failure. Most patients who cannot receive further aggressive treatment will definitely been offered this option.
October 29, 2007
A possible step forward for patients with brain tumor
Analysis of: Avastin seen as helpful against deadly brain tumor | www.reuters.com
Author: GLG Expert Contributor
Pahse-III randomized trials are urged to hoopefully confirmed these data. Should that be the case, even brighter future in sight for avastin.
October 29, 2007
Hope from China?
Analysis of: Satisfactory Anti-Cancer Effects On Hepatocellular Carcinoma Found In A Chinese Medicine | www.medicalnewstoday.com
Author: GLG Expert Contributor
Unless positive data come from well-designed clinical trials conducted elsewhere, it is unlikely to foress a bright future for this agent. Clinical data are definitely more important than in vitro results
October 29, 2007
Forodesine HCL in cutaneous lymphoma
Analysis of: BioCryst initiates enrollment in pivotal trial of forodesine HCL in patients with cutaneous T-Cell lymphoma (CTCL) | www.pipelinereview.com
Author: GLG Expert Contributor
All T-cell lymphoma patients desperately need better treatment options, since no much progress has been made compared to B-cell lymphoma. Forodesine HCL is a promising novel agent which may or may not succeed in the setting of Cutaneous T-cell lymphoma. Should its development proceed smoothly, it might...
October 1, 2007
vaccine for metastatic renal cancer
Analysis of: Immatics Launches Phase 2 Study On Cancer Vaccine IMA901 | www.medicalnewstoday.com
Author: GLG Expert Contributor
70 patients are a very good and potentially informative number Metastatic renal cancer is a tough customer, and therefore a very telling scenario should this trial succeed 10 European countries involved warrant swift consideration for this vaccine, should the ultimate results meet or beat...

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