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GLG News by Cardiothoracic Surgeons who Perform Valvoplasty Procedures (US)

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May 27, 2008
Thrombus Aspiration in Acute MI
Analysis of: Medtronic Says Thrombus Aspiration Before Stenting Betters Survival Rates Of Myocardial Infarction Patients | www.rttnews.com
Author: GLG Expert Contributor
Mechanical thrombectomy of the coronary arteries has becoming increasingly more common with the advent of simpler aspiration catheters.  Although its use in the setting of acute myocardial infarction is even more common, it is not routine.  Randomized data indicating its effect on clinical...
May 19, 2008
Obvious answer - wrong question - NO IMPACT on prescribing
Analysis of: New data show Tekturna HCT® is twice as effective at reducing blood pressure than the diuretic HCT alone | www.novartis.com
Author: GLG Expert Contributor
It is well known that the addition of thiazide diuretic to ACEI or ARB treatment adds about 10 mm Hg reduction on top of the 10 mm Hg reduction provided by the ACEI or ARB agent.  It is expected that blocking renin in the renin angiotensin system with Tekturna would provide a similar result.
February 4, 2008
Understanding the effects of statins in low risk patients.
Analysis of: Great Drug, but Does It Prolong Life? | www.nytimes.com
Author: GLG Expert Contributor
Statin therapy in lower risk populations will not have as profound an effect as in high risk subsets but still very likely has overall positive benefits.
January 25, 2008
Preventing Bariatric Surgery Deaths
Analysis of: Pinning Down Mortality Rates After Bariatric Surgery | www.medscape.com
Author: Forrest Rubenstein, Cardiac, Thoracic and Vascular Surgeon, Rubenstein Cardiovascular and Thoracic Surgery
 Bariatric surgery is a major operative procedure that caries significant morbidity and mortality risks due to the comorbid diseases seen in this patient population.  This procedure is increasing in frequency as more patients are willing to have it and more surgeons are becoming proficient. The...
January 25, 2008
Questions about bleeding, proper dose and appropriate patient subsets will limit use
Analysis of: Daiichi Sankyo, Lilly Submit New Drug Application for Investigational Antiplatelet Drug, Prasugrel, with U.S. Food and Drug Administration | www.pipelinereview.com
Author: GLG Expert Contributor
TRITON-TIMI 38 study of 13,608 patients with ACS compared prasugrel against clopidogrel, combined with aspirin.  Prasugrel reduced the combined rate of CV death, MI or stroke (12.1% for clopidogrel vs. 9.9% for prasugrel). The benefit came at a cost of increased serious bleeding (1.4%, vs....
January 14, 2008
The impact on Vytorin and zetia sales will be modest reduction after the release of ENHANCE data
Analysis of: Schering releases ENHANCE data today | www.tradingmarkets.com
Author: GLG Expert Contributor
Physicians have several possible conclusions that can be taken; These include: - the trial is flawed - the selection of patients with much less CIMT than previous trials such as ASAP and ARBITER flaws the study -  the failure to meet the trial endpoint is only a surrogate and clinical trial data...
August 28, 2007
CMS regulations penalize hospitals for taking care of sickest patients
Analysis of: New Medicare Regulations Adopted To Reduce Certain Hospital Infections And Medical Errors | www.medicalnewstoday.com
Author: Forrest Rubenstein, Cardiac, Thoracic and Vascular Surgeon, Rubenstein Cardiovascular and Thoracic Surgery
This article presents the new CMS guidelines that deny higher payments for the additional costs associated with treating patients for certain hospital - acquired infections and medical errors. While these are laudable goals, to assume that all infections are the result of poor medical practice is an...
August 28, 2007
Retail drugstore clinics - filling a niche ?
Analysis of: Drugstore Clinics Spread, and Scrutiny Grows | www.nytimes.com
Author: Forrest Rubenstein, Cardiac, Thoracic and Vascular Surgeon, Rubenstein Cardiovascular and Thoracic Surgery
   Several large drugstores are establishing retail medical clinics within their stores much as eyeglass stores have had optomitrists on site.  There is no problem with these clinics per se as long as they practice within the scope of the practitioners license and skill.  There are...
August 28, 2007
The drug patent "shell game"
Analysis of: New antihistamine gets FDA green light.(RX CARE)(Levocetirizine (Xyzal) by UCB Inc. and Sanofi-Aventis ) | www.therapeuticsdaily.com
Author: Forrest Rubenstein, Cardiac, Thoracic and Vascular Surgeon, Rubenstein Cardiovascular and Thoracic Surgery
   Zyrtec (cetirizine) is a second generation nonsedating antihistamine that has enjoyed wide popularity.  Zyrtec will become available generically in late 2007 and the generic form is expected to be significantly cheaper.  To virtually extend the patent, the manufacturer is...
August 21, 2007
FIRE STAR™ Rx PTCA Dilatation Catheter - an incremental improvement, not disruptive technology
Analysis of: Cordis Corporation Introduces FIRE STAR™ Rx PTCA Dilatation Catheter | www.medicalnewstoday.com
Author: Forrest Rubenstein, Cardiac, Thoracic and Vascular Surgeon, Rubenstein Cardiovascular and Thoracic Surgery
   Cordis introduced the FIRE STAR™ Rx PTCA Dilatation Catheter to the European market.  This catheter reportedly has a lower profile than other devices on the market which enables it to cross highly stenotic or tortuous lesions.  There are no controlled studies showing device...

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