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GLG News by Cardiac Anesthesiologists (US)

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May 19, 2008
Improving anesthetic/surgical outcomes- the role of pharmacoprophylaxis
Analysis of: Higher Risk of Death and Stroke in Patients Given Beta Blockers After Non-Cardiac Surgery (POISE Trial) | pharmalive.com
Author: GLG Expert Contributor
To most in anesthesia, a "good anesthetic" is when the patient is delivered to the post anesthesia care unit in a stable fashion.  However, it may be more complicated and success is determined by 30-180 day markers of myocardial or CNS morbidity.  Unfortunately, this type of followup is not...
Alex BekkerApril 14, 2008
Investors Have Overreacted: The Use of BIS Devices to Monitor the Depth of Anesthesia Will Not Be Affected by One Negative Article
Analysis of: Anesthesia Awareness and the Bispectral Index | content.nejm.org
Author: Alex Bekker, Associate Professor, Anesthesiology & Neurosurgery, NYU Medical Center
The recent study in the New England Journal of Medicine has suggested that the BIS monitoring system does not reduce the incidence of awareness under anesthesia. The stock of Aspect Medical Systems, the manufacturer of the BIS monitoring system, has lost 40% of its value during the last few weeks. The...
February 18, 2008
A Possible Botox "Black Box" Warning Will Serve No Purpose
Analysis of: FDA Issues Warning About Botox Deaths | www.pharmalot.com
Author: GLG Expert Contributor
1) Dissemination of information on Botox related complications is important.  2) Lay press coverage of Botox related complications will likely transiently reduce Botox utilization. 3) A "black box" warning from the FDA will serve no useful purpose. 
October 29, 2007
Anesiva works in minutes as topical anesthetic for IV access
Analysis of: Anesiva Announces Pivotal Phase 3 Trial of Zingo(TM) Meets Primary Endpoint and Significantly Reduces Venous Access Pain in Adults | www.bio-medicine.org
Author: GLG Expert Contributor
Anesiva represent a significant advantage over EMLA cream in that it works in 1-3 minutes as opposed to the need for 1 hour placement prior by EMLA cream.  Besides the pediatric population there are many adult patients with needle phobia and this fast paced world needs a quicker acting...
October 29, 2007
The real danger is alarming the public !
Analysis of: Generic Drugs: Dangerous Differences? | abcnews.go.com
Author: GLG Expert Contributor
Dangerous drugs, news at 11 !  Until you can show human studies of differences between generic drugs and brand drugs it is irresponsible to scare the public.  These broad stroke scare tactics have no place in our logic based scientific community.
October 29, 2007
Organon to no longer be manufacturer of Zemuron and Norcuron ?
Analysis of: Schering-Plough Receives Approval from European Commission for Planned Acquisition of Organon BioSciences N.V. | www.pipelinereview.com
Author: GLG Expert Contributor
For my entire career I have had Organon as the maker of Vecuronium and then Rocuronium.  I am always concerned with change as it is not always for the better.  I and other Anesthesiologists will be keeping an eye on the progress and effects of this potential takeover.
October 19, 2007
CMS can't possibly know what is Medically preventable, only know how to prevent paying
Analysis of: Nonpayment for Performance? Medicare's New Reimbursement Rule | content.nejm.org
Author: GLG Expert Contributor
I have been practicing Medicine for 14 years and have seen that despite excellent care complications still occur.  For CMS to state that there are 8 diagnoses that are preventable is preposterous.  This is such an outrage that every Physician and Hospital employee should write their ...
October 16, 2007
The relief of osteoarthritis knee pain occurred due to placement of Acupuncture needle, regardless of site
Analysis of: Scharf HP, Mansmann U, Streitberger K, Witte S, Kra¨mer J, Maier C, et al.Acupuncture and knee osteoarthritis: a three-armed randomized trial. Ann Intern Me2006;145:12-20. [PMID: 16818924]d. | www.annals.org
Author: GLG Expert Contributor
I find this very interesting that patient's experienced pain relief regardless whether it was Sham Acupuncture or Traditional Chinese Acupuncture.  The study may have been unblinded too early but with 1007 paients I do believe it was powered enough.  Further study would be helpful to also include...
October 15, 2007
Transfusion Transformation ?
Analysis of: Nitric Oxide Restores Transfusion Efficacy | www.medpagetoday.com
Author: GLG Expert Contributor
This may be the most important finding this year.  This could completely transform the way we transfuse patients.  Obviously we need to be able to reproduce these results in humans, but this is still an article with great sigmificance.
October 15, 2007
Who is going to take care of the patient with complication after surgery abroad ?
Analysis of: Shire's New ADHD medication, VYVANSE(TM) (lisdexamfetamine dimesylate) Now Available in U.S. Pharmacies Nationwide | www.eurekalert.org
Author: GLG Expert Contributor
While I agree with the  premise that patients will go where it is more affordable.   What happens upon their return if there is a complication ?  This is my concern with this type of "Medical Tourism" and makes this article important to all Health Professionals.

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