GLG News by Byetta Prescribers for Diabetes: Endocrinologists

1. Yes, more expensive glucose-lowering drugs are being more widely used. 2. No, I do not think that medical evidence suggests that this is incorrect.

1.Hypertriglyceridemia causes pancreatitis 2.Most PCP, endocrinologists, and cardiologists are not effectively treating high triglycerides, and may make it worse by recommending a low fat = high carb diet 3.Accord data with 75% reduction in death, and patients desparate for wt loss will continue to...

Most hospitals are financially built on their heart programs. The "agressive" medical arm is conservative by our standards yet as good as stents at far less cost. If this was truly pursued by large companies with TPA insurance plans, their overall cost would drop with large savings in healthcare costs....

The ACCORD trial results were no suprise to our diabetes practice. We have been heavy users of Byetta since launch in 2005, and have seen the same results in our population of > 2000 diabetics with over 700 on Byetta. Since the Simpson et al study in the Canadian Journal of Medicine (CMAJ 2006;174(2):169-74)...

The recent finding that Byetta therapy decreased mortality in the ACCORD study needs to be replicated in studies designed to address that point.  Even if it is replicated and statistically significant, it probably will not be true for the widely anticipated once weekly extended formulation...

Therapeutic effects of drugs are seen essentially in all treated patients.  Adverse outcomes are infrequent.  The July 1-2 FDA diabetes panel recommendation that sturdy systems for determining outcome should be required for all new diabetes treatments may lead to a >100-fold increase in...

As exciting as the DURATION I study results have been, Roche's GLP-1 agonist is also looking good in earlier phase trials, and there are MANY competitors in this GLP-1 realm, as well as the gliptins (oral, with similar efficacy on glucose and A1c but without the dramatic weight loss), chomping at the...

This compound may have additiional benefit in type 2 diabetic patients, especially those with the cardiometabolic syndrome. 

It is simply shameful that studies on the syndrome of insulin resistance keep being published by groups that have poor understanding of the pathophysiology of the main aging pathway that has been described up to date. Obesity, waist to hip ratio and triglycerides (TG) are biased by many factors,...

I am a heavy user of ARB's and Tekturna.  This article does not really show anything of significance.  Most practicing physicians have seen much better results and much better tolerability with ARB's than diuretics. I do not think this is going to change prescribing habits of anyone. ...