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October 24, 2008
A target may well decrease the market for EGFR inhibitors (Erbitux & Vectibix) in colon cancer (CRC)
Analysis of: Targeting EGFR in Colorectal Cancer | content.nejm.org
Author: GLG Expert Contributor
Measuring mutated K-RAS will show who will NOT respond to ImClone's Erbitux or Amgen's Vectibix. Thus to use either in CRC will not be particularly effective.
October 23, 2008
Vaccinate smokers?? what is the agenda and the employer of "The Advisory Committee on Immunization Practices."
Analysis of: Panel Calls for Vaccine for Adult Smokers | online.wsj.com
Author: GLG Expert Contributor
31 million more doses of Pneumovax yearly in the US??
October 21, 2008
GVAX: Why did it fail? Let me list the possible ways......
Analysis of: Cell Genesys Announces Termination of VITAL-1 Phase 3 Trial of GVAX Immunotherapy for Prostate Cancer | pharmalive.com
Author: GLG Expert Contributor
Cell Genesys is basically stopping work on GVAX inview of failure in two trials. The cause of the failure is not readily apparent.
October 15, 2008
Thyroid cancer: When it rains it pours
Analysis of: Phase II Trial of Sorafenib in Advanced Thyroid Cancer | jco.ascopubs.org
Author: GLG Expert Contributor
 as per an accompanying editorial "In conclusion, it is particularly gratifying that years of research in tumor biology and drug development have coalesced. Translation of these research advances into therapeutic benefits for patients with refractory thyroid cancer, and a related paradigm shift...
October 15, 2008
Genetically determined cancer therapy: It will be a wash.
Analysis of: Genetic Research May Help Pick Patients' Best Cancer Drugs | online.wsj.com
Author: GLG Expert Contributor
Genetic determinants will decrease use of some drugs due to mutations such as Kras which indicate less chance of response and thus the chemo agents will not be used.
October 8, 2008
Avastin/Tarceva/Roche/OSI/Genentech: So much for "synergy" in lung cancer
Analysis of: Genentech Set Back by Cancer-Drug Study | online.wsj.com
Author: GLG Expert Contributor
The primary goal was improved survival- NOT REACHED!!
October 6, 2008
Government Intervention is Here: Pharma had better get use to it....
Analysis of: Roche Cuts Price of Cancer Drug | online.wsj.com
Author: GLG Expert Contributor
"U.K. Health Service Agrees to Pay for Tarceva Following the Company's Discount" so that the price is equivalent to Taxotere.
October 3, 2008
Radon & Lung cancer: Outside of Uranium Mines is it Relevant???
Analysis of: Protecting a Home From Silent Threat | www.nytimes.com
Author: GLG Expert Contributor
Radon is responsible for about 15% on lung cancer deaths in the US??
October 2, 2008
Idera Pharma: is there room for another agent in recurrent renal cell ca??
Analysis of: Idera Pharmaceuticals Announces Preliminary Data from Phase 2a Clinical Study of IMO-2055 Monotherapy in Renal Cell Carcinoma | www.pipelinereview.com
Author: GLG Expert Contributor
Apparently Merck has an interest in this compound and it is in trial in combination in other neoplasms.
September 30, 2008
Epo & Stroke: The chickens coming home to roost.
Analysis of: F.D.A. Reviewing Deaths in Anemia Drug Study | www.nytimes.com
Author: GLG Expert Contributor
Epo (J & J's version) increased mortality when given to patients with a new stroke in an effort to improve brain function. What will this lead too?? 

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