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GLG News by Addiction Medicine Psychiatrists (US)

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May 8, 2007
Fight the cells that cause the damage
Analysis of: MacroGenics and JDRF Sealed Partnership to Support Pivotal Phase II/III Clinical Trial of Anti-CD3 Monoclonal Antibody for Children and Adults with Recent-Onset Type 1 Diabetes | www.pharmagazette.com
Author: GLG Expert Contributor
Anti-CD3 antibodies such as teplizumab (MGA031, hOKT3-gamma-1 (Ala-Ala)) are engineered to block the function of CD3 cells, immune T cells that orchestrate the destruction of islets. This prevents "activation" of the T cells after they have identified their target, disarming them once they are poised...
May 8, 2007
Problem eating is not gender-limited and it is part and parcel of the "obesity epidemic"
Analysis of: Men, Boys Lack Options to Treat Eating Disorders | online.wsj.com
Author: GLG Expert Contributor
If one takes the perspective that eating too little and eating too much are simply different sides of the same coin, the female limited focus on anorexia nervosa does not make much sense.  Surely men and women are different, but using food or restricting food to meet emotional needs is pretty common...
May 1, 2007
Generics hit the mark and save you money
Analysis of: Caraco Pharmaceutical Laboratories Ltd. Announces FDA Approval To Market Generic Ambien(R) | www.medicalnewstoday.com
Author: GLG Expert Contributor
Zolpidem is very widely used and the generic should have a substantial market.
April 30, 2007
There are only so many hours in a day--so if you spend a lot of time at the casino...
Analysis of: Health Effects Of Casinos Have Been Ignored, Say Experts | medicalnewstoday.com
Author: GLG Expert Contributor
Pathological gambling rates vary to some degree with the availability of opportunies to gamble.  Gambling venues provide tremendous profits to both the casino industry and the governments who tax their revenues. 
April 30, 2007
Is Bariatric surgery for type 2 diabetes mellitus an overly simplistic solution
Analysis of: Bariatric surgery - possible treatment for type 2 diabetes mellitus | www.news-medical.net
Author: GLG Expert Contributor
There is reasonably good data emerging that bariatric surgery can be effective in treating obesity related complications.  However, as the prevalence of bariatric surgery increases in the U.S. in an exponential manner, there are many patients who have received this surgery without us knowing the...
April 30, 2007
It may be quite naive to choose your wine based on resveratrol content
Analysis of: Is Your Favourite Red Wine Really That Good For You? | www.medicalnewstoday.com
Author: GLG Expert Contributor
The data on benefits of antioxidants in wine are sufficiently tenuous that I would not build an edifice on measuring resveratrol in favorite wines to determine which wine to choose to drink.
April 30, 2007
Honey, no headache tonite!
Analysis of: Trial Information: A Phase III, Double-Blind, Placebo-Controlled safety and efficacy trial of Flibanserin 25mg/twice a day and 50mg/once and twice dai | www.centerwatch.com
Author: GLG Expert Contributor
The relationship between sexual drive and depression is one of the great unexplained enigmas.  It is, in my opinion, no coincidence that many of the antidepressants currently on the market have as a side effect reduced libido (sex drive).  Moreover, it is interesting that improvement of mood...
April 30, 2007
An Insurance Company Facilitates Healthcare for a Change
Analysis of: CIGNA Behavioral Health Program Reduces Overall Health Care Costs and Improves Patient Outcomes | www.prnewswire.com
Author: GLG Expert Contributor
That clinical case management improves outcome and reduces costs is nothing new.  What is new is that this service is provided by the insurance company.  What is not clear is what this insurance provided service actually costs and does.
March 28, 2007
How far have we come with antidepressant development--or are the monoamines the answer?
Analysis of: Triple Reuptake Inhibitors: What to Expect from “Mega-Andipressants” | www.currentpsychiatry.com
Author: GLG Expert Contributor
I am getting tired of the monoamine hypothesis of depression.  This "tripple threat" neurotransmitter reuptake inhibitor sounds to me like just the latest version of a long and rather exhausting story.  The future for antidepressants lies in getting beyond the monoamines.
March 28, 2007
Dark chocolate--how sweet it is!
Analysis of: Dark Chocolate May Lower Risk Of Cardiovascular Disease | www.medicalnewstoday.com
Author: GLG Expert Contributor
Dark chocolate contains antioxidants which may improve endothelial functioning.  Endothelial dysfunction has been implicated in cardiovascular complications of smoking, hyptertension, diabetes, angina, coronary artery disease, etc.

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