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GLG News by Addiction Medicine Psychiatrists (US)

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May 28, 2007
Long-acting Seroquel: Astra-Zeneca Continues to Zoom to the top
Analysis of: FDA Approves Astrazeneca's Once-Daily Seroquel XR Extended-Release Tablets for the Treatment of Schizophrenia | www.therapeuticsdaily.com
Author: GLG Expert Contributor
With the introduction of once-daily Seroquel XR, Astra-Zeneca will continue to dominate the market for 'atypical' antipsychotics.  While many such changes are merely patent extenders, this one promises to be therapeutically useful: given the short-acting nature of the quetiapine...
May 23, 2007
The U.S. market likes Viagra--why not a stiff tongue for sleep apnea?
Analysis of: Aspire Medical Announces First Implant In US And Start Of Clinical Trial To Treat Sleep Apnea | www.medicalnewstoday.com
Author: GLG Expert Contributor
Obstructive sleep apnea is very common.  If an implant can prevent the tongue from obstructing the airway during sleep, it should prove quite valuable. 
May 21, 2007
Eat healthfully and you are less likely to get sick
Analysis of: 'Mediterranean' Diet Reduces COPD Risk | www.medpagetoday.com
Author: GLG Expert Contributor
This report is the latest in a series of analyses showing that diet influences disease.  Consumption of the Mediterranean diet is negatively associated with new diagnoses of COPD, even when major confounding variables are statistically removed.  The mechanism(s) for this effect are not elucidated,...
May 21, 2007
Will the extended release formulation mitigate abuse potential of quetiapine
Analysis of: FDA Approves Astrazeneca's Once-Daily Seroquel XR Extended-Release Tablets for the Treatment of Schizophrenia | www.therapeuticsdaily.com
Author: GLG Expert Contributor
Seroquel (quetiapine) is not a particularly potent neuroleptic that has developed significant street value, or abuse potential, among patients who are prescribed this medication.  The foremost question in my mind (rather than the issue of enhanced compliance due to once daily dosing) is whether...
May 15, 2007
When you claim you are giving a certain dose of a medication you should deliver
Analysis of: Recall of Two Valproic Acid Drugs, Depakene 500 mg and Ratio-Valproic 500 mg | pharmalive.com
Author: GLG Expert Contributor
This recall emphasizes a fundamental concept required by medication regulatory agencies in all countries, namely that you have to deliver on your claim.  If you are selling 500mg of a drug, that much of the drug needs to be available after dissolving the medication in your stomach.
May 15, 2007
Treatment of ADHD: stuck between a rock and a hard place
Analysis of: Shire to Present New Scientific Data on ADHD Treatment Portfolio at APA Annual Meeting | www.shire.com
Author: GLG Expert Contributor
So many people with ADHD develop co-occuring alcohol or drug dependence.  If you read Shire's warning box, they caution against giving their medications to individuals with drug addiction.  The question an astute analyst will come up with is "who should be prescribed these medications?"
May 14, 2007
Telemedicine could address the needs of psychiatry in which there is a distinct shortage of trained psychiatrists compared to those who need their services
Analysis of: Remote Patient Monitoring and Disease Management Solutions Key to Promoting Growth in U.S. Tele-Health Solutions Market | sev.prnewswire.com
Author: GLG Expert Contributor
Telemedicine is generally considered to be most useful for "hard" disciplines like reading EKGs or radiological images, however, it has applications for extending expertise in psychiatry.  Increased recognition of the contribution of psychiatric problems to all of medicine and relative undersupply...
May 14, 2007
Knowing what is wrong does not necessarily mean you will do anything about it
Analysis of: BioSignia Announces Agreement to Deliver Chronic Disease Prediction Technology Through Regional Pharmacy Chain Kerr Drug | www.sbwire.com
Author: GLG Expert Contributor
The notion of health awareness is intuitively a good thing.  But will the individual who is informed of these "numbers" really change their lifestyles to normalize said number?  I am not sure this has been adequately tested or proven.
May 9, 2007
Too much of a good thing?
Analysis of: Could Calcium and Vitamin D Cause Brain Lesions? | www.ivanhoe.com
Author: GLG Expert Contributor
Calcium supplementation has become very prevalent.  Also, as the population ages, so has cognitive slippage and dementia.  The liklihood of a correlation may increase for other reasons than causality, among them that this is a population in which depression is being studied and depression...
May 9, 2007
ACE Inhibitors may affect the brain in as yet unknown ways
Analysis of: BP drugs may cut Alzheimer risk | timesofindia.indiatimes.com
Author: GLG Expert Contributor
This new finding suggesting that ACE inhibitors may protect neurocognitive functions in elders begs the question of whether this is a direct or indirect action of these widely used drugs.  Regardless of the mechanisms, such findings are potentially very important.  These findings are reminscent...

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