FDA Alert: Hemorrhagic or Necrotizing Pancreatitis in Patients Taking Byetta

Patients will be reluctant to take and physicians are much less likely to use till this issue is clarified.

1.Hypertriglyceridemia causes pancreatitis 2.Most PCP, endocrinologists, and cardiologists are not effectively treating high triglycerides, and may make it worse by recommending a low fat = high carb diet 3.Accord data with 75% reduction in death, and patients desparate for wt loss will continue to drive sales

If truly an association, this will alter the use of this drug.

Any new drug being marketed is always slow to gain popularity clinical practice until time and patient tested.  These new health alerts in association with Byetta will most likely make doctors more wary about starting Byetta in a patient who has underlying risk factors for pancreatitis. This article is good but does not address how long the patients were on Byetta before symptoms began. ...

The recent publication of new cases of pancreatitis that are occurring in patients taking Byetta (exenatide) can't be good for Amylin/Lilly. While Byetta and investigational GLP-1 analogs are still very viable therapeutics for Type 2 Diabetes, prescribers will have to reassess the risk-benefit ratio for many patients given the new information. The long-acting form of Byetta (LAR) may suffer the most...

At first, it appeared that the reports linking Byetta and pancreatitis were likely due to an association between pancreatitis and the underlying pathology in patients receiving Byetta (obesity, diabetes, gall stones, and hypertriglyceridemia). However, the additional cases of (sometimes fatal) necrotizing pancreatitis are worrisome for a number of reasons including: 1) the severity of the...

 1. As Byetta is not monotherapy and the clinical trial results  are  not clear about the condition od trial patient, so future of Byetta is  blink