ACE Inhibitor May Ease Cardiac Risks in Marfan's Syndrome

In this small and short-duration study, ACE inhibitors seem to provide an additional preventive benefit when used with beta blockers in patients with marfan's syndrome. This is all to the good for those patients, and if the results of this preliminary study are borne out over a longer term, this may reduce the eventual need for aortic root surgery in these patients.

ACEI are known for their ability to reduce afterload effectively and even to contribute favorably to cardiac remodeling in heart failure. Results described, therefore, are logical, even though some "statistically significant" differences, like reduction of mean pressure by 1 mm Hg, are not clinically significant.