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February 19, 2008

improve Overall survival in prostate cancer

Analysis of: Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival | www.pipelinereview.com
This analysis is solely the work of the author. It has not been edited or endorsed by GLG.
Analysis By:
Taral Patel, MD, OncologistTaral Patel, MD
Oncologist, Mid Ohio Oncology Hematology Inc.
Implications: esults showed that PROVENGE patients experienced improved survival if they received more cells across the three doses of PROVENGE (higher cumulative TNC count (p=0.019)) or higher cumulative CD54 upregulation values (p=0.009). The effect on survival for TNCs appeared to reflect in part the patients' baseline prognostic factors. However, the CD54 upregulation ratio appeared to be an independent predictor of survival in patients who received PROVENGE, as the correlation remained strong even after adjusting for baseline prognostic factors (p=0.022). Data is very impressive. This may lead FDA approval in prostate cancer in next 3-6 months.

Analysis: Data is very impressive.
This may lead FDA approval in prostate cancer in next 3-6 months.

Other Analyses of the Same Source Article:
More misleading Provenge data from Dendreon
February 20, 2008, Author: Eric Whitman, MD, Medical Director, Office of Grants and Research, Atlantic Health System Inc
Good Step, but Still a lot of Details to Check
February 19, 2008, Author: GLG Expert Contributor

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