The Black box warning of the Calcineurin inhibitors is faulty

Implications: I totally agree with this article. The conclusions from the FDA are incorrect, and the data appear to indicate that the TCI's are actually protective!!!! In any event it has created a false sense of a problem, where none exists, and decreases the use of these agents, which are safer than the existing steroid therapies!!!

Analysis: I disagree with the warning. The conclusions are faulty, and the data suggests that the TCI's may actually be protective against cancer!!! I still use these agents both alone and in combination, and have found them to be useful, and probably safer than topical steroids!