Hedgehog pathwa drugs and chemotherapy

Implications: Hedgehog path new and will improve on chemo/biologic therapy available for colorectal cance Past attempts at ading to regimens have not always been successful ie PACE

Analysis:  The introduction of a new agent to cancer therapy is always interesting. It remains to be seen how the drug interacts with conventional chemotherapy. In some cases it orks and in others it doesn't and may even have disadvantages over chemotherapy without the new drug. It is difficult to predict how these things will turn out and this has been demonstrted tim and time again when one uses the basis for their project"if one drug works good, more will work better". the hedghog path is a tumor repir and growth pathway, but one can see how inhibiting this process can either be good or bad. The only outcome that will be a success is of course a significant improvemnt and with a disease like colorectal cancer PFS may not be enough , as there areso may regimens being developed to salvage patients.