Evolence: Will this New "Advanced" Collagen Filler Take Hold?

Implications: Evolence is an injectable filler material that is made by an "advanced collagen GLYMATRIX™ Technology."  Collagen has generally fallen out of favor amongst aesthetic physicians due to its short duration of action.  Evolence will have to demonstrate that it is superior to the plethora of other injectable filler materials currently available to gain market share.  To do so will not only require clinical efficacy, it will also require a tremendous marketing effort to penetrate a market where there is no shortage of injectable filler materials from which to choose.

Analysis: The market currently has a variety of injectable filler materials from which to choose.  The leaders are hyaluronic acid-based materials such as Restylane/Perlane (Medicis) and Juvederm Ultra/Juvederm Ultra Plus (Allergan).  Other fillers that are widely used include Radiesse (BioForm) and Scultpra (Dermik/Sanofi-Aventis).  Artefill (Artes Medical) is also used, though not as widely due to many concerns due to its permanence.  Evolence introduces collagen back into the market.  Previously, collagen based products either required allergy testing (e.g., Zyderm/Zyplast) or were relatively short in its duration of effect (e.g., CosmoDerm/CosmoPlast).  If Evolence can demonstrate some superiority over the plethora of products currently available, it may gain some market share.  However, to do so will require a tremendous marketing effort and potential financial incentives as well.