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September 3, 2007

?Role of IMC-A12 for metastatic prostate cancer

Analysis of: Phase II Study of IMC-A12 for Advanced Prostate Cancer Commences Patient Enrollment | www.pipelinereview.com
This analysis is solely the work of the author. It has not been edited or endorsed by GLG.
Analysis By:
Mitchell Bamberger, MD
Attending Physician, Tri-County Urology
Implications: This immunotherapy is based upon Insulin-like growth factor which may be expressed in prostate cancer.  There is not much data on this.  The study is very limited, 30 patients, and must not have received any chemotherapy prior to enrolling.  The sponsor is IM Clone.  I do not know what research institutions will be enrolling patients.  A limited investigation is warranted, but the data will be crucial if to go on to a Phase III trial

Analysis: I am suspicious as I am not very aware of any significant role for IGF for prostate cancer. I believe these studies should be carried out, but I wouldn't hold my breath on this.  Too many of this type of studies have been done, with too much emphasis, and very little yield.


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