- Definition: Extended-spectrum beta-lactamases
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The Enterobacteriaceae may produce extended-spectrum beta-lactamases (ESBLs). These enzymes can destroy most beta-lactam antibiotics and lead to multi-drug resistance. The treatment of choice of ESBL-producing organisms is usually an antibiotic of the carbapenem class. Unfortunately, another beta-lactamase type, the KPC beta-lactamases are now occurring in some areas and are responsible for resistance to carbapenems.
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