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GLG News in Healthcare

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October 27, 2008
K-ras testing will be a reality soon, Bad news for EGFR inhibitors, but good news for Avastin
Analysis of: Targeting EGFR in Colorectal Cancer | content.nejm.org
Author: GLG Expert Contributor
K-Ras mutaions analysis in colorectal cancer may become a pre-requiste for use of anti-EGFR antibodies in therapy Erbitux and Vecitibix use may be relegated to less number of cases. This will benefit Avastin ( Genentech) whose mechanism of action is independent of these mutations
Donald FlemingOctober 27, 2008
Hitting the target may reduce the use of targeted cancer drugs or not
Analysis of: Targeting EGFR in Colorectal Cancer | content.nejm.org
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
We are facing an ever increasing expense of treating cancver The so called targeted drugs are the big price items The recent discovery of theses drugs have sometimes been out of order with understanding their activity
October 27, 2008
Medtronic Endeavour Failing to Live Up to Expectations
Analysis of: Medtronic Endeavor Heart Stent Tied to Complications | www.bloomberg.com
Author: GLG Expert Contributor
The Endeavour stent appears to have a higher restenosis rate than currently marketed Drug Eluting Stents without the improved safety profile claimed by the company.  This finding is at odds with the companies marketing message to cardiologists.  These studies, along with the introduction of Xience/Promus, and the lack of a rapid exchange platform will limit Medtronics ability to break into...
October 27, 2008
Health IT About to Become a Global Force for Change
Analysis of: Prescription for Change | online.wsj.com
Author: GLG Expert Contributor
The health care industry is on the brink of joining the 21st Century (or at least the late 20th Century).    Healthcare is about to undergo a global revolution that it can no longer resist with information technology as the fuel.  This transformation will occur because the previous barrier to more widespread adoption of health IT concerning the ability to assure...
Adam SchaffnerOctober 27, 2008
Bold Contest for a Daunting Problem
Analysis of: WellPoint, X Prize launch $10M health care contest | news.yahoo.com
Author: Adam Schaffner, Plastic and Reconstructive Surgeon, The Detroit Medical Center
Most people agree that the healthcare system in the United States is in need of a complete overhaul.  Unfortunately, the many competing interests in the current system make such overhaul extremely challenging.  This contest certainly provides much incentive for the best and brightest to put forth their ideas on how to improve the system.  Overcoming...
October 24, 2008
A target may well decrease the market for EGFR inhibitors (Erbitux & Vectibix) in colon cancer (CRC)
Analysis of: Targeting EGFR in Colorectal Cancer | content.nejm.org
Author: GLG Expert Contributor
Measuring mutated K-RAS will show who will NOT respond to ImClone's Erbitux or Amgen's Vectibix. Thus to use either in CRC will not be particularly effective.
Donald FlemingOctober 24, 2008
The vaccine approach to cancer has yet to succeed
Analysis of: Cell Genesys Announces Termination of VITAL-1 Phase 3 Trial of GVAX Immunotherapy for Prostate Cancer | pharmalive.com
Author: Donald Fleming, Division Head of Hematology and Oncology, Davis Health System, Inc.
Be cautious of vaccine approaches to cancer No cancer has had success with the use of vaccine therapy We are far from figuring out the reason for failure of vaccines to treat cancer
October 23, 2008
Vaccinate smokers?? what is the agenda and the employer of "The Advisory Committee on Immunization Practices."
Analysis of: Panel Calls for Vaccine for Adult Smokers | online.wsj.com
Author: GLG Expert Contributor
31 million more doses of Pneumovax yearly in the US??
October 22, 2008
skepticism
Analysis of: WellPoint, X Prize launch $10M health care contest | news.yahoo.com
Author: GLG Expert Contributor
The HC system is a 2 trillion ton gorilla -- proving that an idea can move it, doesn't mean that it will. The incentives to improve efficiency in healthcare already greatly surpass 10 million dollars, though maybe not for the right people.
October 22, 2008
Performance enhancing or potential problem?
Analysis of: Brain boost drugs 'growing trend' | news.bbc.co.uk
Author: GLG Expert Contributor
When I hear, "If these cognitive enhancing drugs make our lives better and make us better able to concentrate and better able to perform, this would surely be a good thing." my mind logically relates this to the well known performance enhancing drugs used by some athletes.  Not to say that these "brain boosters" have the same deleterious side effects of steroids, but the fact that dependency...
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