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GLG News by this Author
Analyses are solely the work of the authors and have not been edited or endorsed by GLG.
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Saxagliptin - third gliptin on the EU market
October 8, 2009
ONGLYZA™ (saxagliptin) Receives Marketing Authorisation In Europe For The Treatment Of Type 2 Diabetes | www.pipelinereview.com
Besides Sitagliptin and Vildagliptin there will be now a 3rd gliptin available in Europe. Whereas vildagliptin officially needs monitoring of the liver enzymes, at least according to the P.I., and there are new warnings for pancreatitis for sitagliptin no such limitations are known to me at the moment. I do not think that there will be major advantages for saxa compared with sita or vilda, however, we will have to wait and see.
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Life-extending effect of Byetta ?
August 13, 2008
Lilly Diabetes Drug Shows a Life-Extending Promise | www.nytimes.com
In a small subgroup of type-2-diabetes patients in the ACCORD trial which had been treated with Byetta (825 of 10 000) a lowerde death rate was found as compared to the whole group. This is a hypothesis-generating finding. Fewer hypoglycemias, even mild ones, may be an exüplanation for this result which, however, awaits bigger studies planned to answer this question
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A new gliptin - what is the difference to sita- and vildagliptin?
July 29, 2008
As the member of an Advisory board for a gliptin ande not familiar with details on saxagliptin it would be interested to know what makes the difference to the gliptins already on the US and EU market. How is the DPP-4-specifity? Only for DDP-4 or also somewhat for DPP-9? Or other DPP´s ? What´s on with the transaminases? How often a day should it be given? Any other than sita- and vildagliptin regarding weight - only "neutral"?
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